潜伏性结核感染治疗对结核感染T细胞检测（QuantiFERON-TB Gold）结果的影响评估。
Evaluation of the effect of treatment of latent tuberculosis infection on QuantiFERON-TB gold assay results.
作者信息
Pollock Nira R, Kashino Suely S, Napolitano Danielle R, Sloutsky Alex, Joshi Swati, Guillet Jasmine, Wong Michael, Nardell Edward, Campos-Neto Antonio
机构信息
Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts 12215, USA.
出版信息
Infect Control Hosp Epidemiol. 2009 Apr;30(4):392-5. doi: 10.1086/596606.
Abstract
To evaluate the utility of the QuantiFERON-TB Gold assay for monitoring latent tuberculosis treatment efficacy, the assay was performed serially for healthcare workers receiving isoniazid therapy. After 9 months of isoniazid therapy, all of these healthcare workers remained QuantiFERON-TB Gold positive, and cellular proliferation assays revealed persistently strong purified protein derivative responses. These results do not support the use of the QuantiFERON-TB Gold assay to monitor therapy.
摘要
为评估结核感染T细胞检测（QuantiFERON-TB Gold）在监测潜伏性结核治疗效果方面的效用，对接受异烟肼治疗的医护人员进行了系列检测。异烟肼治疗9个月后，所有这些医护人员的结核感染T细胞检测仍为阳性，且细胞增殖试验显示纯化蛋白衍生物反应持续强烈。这些结果不支持使用结核感染T细胞检测来监测治疗。
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