在腮腺炎疫情中评估减毒活疫苗S79的有效性：一项匹配病例对照研究。
Evaluation of live attenuated S79 mumps vaccine effectiveness in mumps outbreaks: a matched case-control study.
作者信息
Fu Chuan-xi, Nie Jun, Liang Jian-hua, Wang Ming
机构信息
Guangzhou Center of Disease Control and Prevention, Guangzhou, Guangdong 510080, China.
出版信息
Chin Med J (Engl). 2009 Feb 5;122(3):307-10.
BACKGROUND
Mumps virus infection is a potentially serious viral infection of childhood and early adulthood. In China, live attenuated S(79) mumps vaccine has been licensed for pediatric use since 1990. The objective of this study was to determine the effectiveness of live attenuated S(79) mumps vaccine against clinical mumps in outbreaks.
METHODS
Cases were selected from mumps outbreaks in schools in Guangzhou between 2004 and 2005. Each case was matched by gender, age and classroom. Vaccination information was obtained from Children's EPI Administrative Computerized System. Vaccine effectiveness (VE) was calculated for 1 or 2 doses of S(79) vaccine with 95% confidence intervals (CI).
RESULTS
One hundred and ninety-four cases and 194 controls were enrolled into the study. VE of the S(79) mumps vaccine for 1 dose versus 0 confer protection 80.4% (95% CI, 60.0%-90.4%) and VEs against mumps in outbreaks for 1 dose of mumps vaccine are similar among those children aged 4-9 years and aged over 10 years old.
CONCLUSION
The live attenuated S(79) mumps vaccine can be effective in preventing clinical mumps outbreaks.
背景
腮腺炎病毒感染是儿童期和成年早期一种潜在的严重病毒感染。在中国，自1990年起减毒活S（79）腮腺炎疫苗已获许可用于儿童。本研究的目的是确定减毒活S（79）腮腺炎疫苗在疫情中预防临床腮腺炎的有效性。
方法
病例选自2004年至2005年广州学校的腮腺炎疫情。每个病例按性别、年龄和班级进行匹配。疫苗接种信息从儿童计划免疫管理计算机系统中获取。计算1剂或2剂S（79）疫苗的疫苗有效性（VE）及其95%置信区间（CI）。
结果
194例病例和194名对照纳入研究。1剂S（79）腮腺炎疫苗相对于0剂的疫苗有效性为80.4%（95%CI，60.0%-90.4%），在4至9岁和10岁以上儿童中，1剂腮腺炎疫苗在疫情中预防腮腺炎的疫苗有效性相似。
结论
减毒活S（79）腮腺炎疫苗可有效预防临床腮腺炎疫情。
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