Departments of Medicine and Radiology, University of Washington, Seattle, WA 98195, USA.
Curr Cardiol Rep. 2009 Mar;11(2):141-7. doi: 10.1007/s11886-009-0021-0.
Congestive heart failure increasingly contributes to the overall morbidity and mortality associated with cardiovascular disease. Although significant advances in therapies allow patients to feel better and have improved functional status and survival, not all patients respond equally to these therapies. Moreover, for any given level of left ventricular systolic dysfunction, it is difficult to predict who will have progressive heart failure leading to death or transplantation or who will die suddenly. It has long been recognized that the sympathetic nervous system plays a major role in the morbidity and mortality associated with congestive heart failure from systolic left ventricular dysfunction. Although some of the sympathetic effect occurs at the systemic level, malfunction at the ventricular myocyte-sympathetic nerve terminal interface is likely a major contributor to sudden death and progressive heart failure. Imaging the cardiac sympathetic nervous system can be used to evaluate this myoneural interface and to predict outcome.
充血性心力衰竭越来越多地导致与心血管疾病相关的整体发病率和死亡率。尽管治疗方法的显著进步使患者感觉更好，并且具有改善的功能状态和生存率，但并非所有患者对这些治疗的反应都相同。此外，对于任何给定水平的左心室收缩功能障碍，很难预测谁将出现进展性心力衰竭导致死亡或移植，或者谁将突然死亡。长期以来，人们一直认为，交感神经系统在与收缩性左心室功能障碍相关的充血性心力衰竭的发病率和死亡率中起主要作用。尽管一些交感效应发生在全身水平，但心室肌细胞-交感神经末梢界面的功能障碍可能是导致猝死和进行性心力衰竭的主要原因。心脏交感神经系统的成像可用于评估该肌神经界面并预测结果。
