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肺癌脑实质及软脑膜转移经颅脑放疗后使用卡培他滨出现显著疗效。

Dramatic response with capecitabine after cranial radiation to the brain parenchymal and leptomeningeal metastases from lung cancer.

作者信息

Paydas Semra, Bicakci Kenan, Yavuz Sinan

机构信息

Cukurova University, Faculty of Medicine, Department of Oncology, Turkey.

出版信息

Eur J Intern Med. 2009 Jan;20(1):96-9. doi: 10.1016/j.ejim.2008.04.015. Epub 2008 Jun 25.

DOI:10.1016/j.ejim.2008.04.015
PMID:19237101
Abstract

It is known that the prognosis of Non Small Cell Lung Cancer with brain metastasis are very poor with a median survival of only a few months. Although some chemotherapeutic agents penetrate the blood brain barrier generally chemotherapy results are bad but efficiency may be better after radiotherapy. For this reason brain metastatic disease requires some efforts to improve the response rate. Here we reported a case with lung cancer metastatic to the brain and we discussed the good response to capecitabine after cranial radiotherapy (C).

摘要

已知伴有脑转移的非小细胞肺癌预后非常差,中位生存期仅几个月。尽管一些化疗药物可穿透血脑屏障,但总体化疗效果不佳,不过放疗后疗效可能更好。因此,对于脑转移疾病需要做出一些努力来提高缓解率。在此,我们报告了一例肺癌脑转移病例,并讨论了头颅放疗(C)后对卡培他滨的良好反应。

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