Khan Fahmi Yousef, Lutof Abdu Kaed, Yassin Mohamed A, Khattab Mohammed Abu-, Saleh Muhannad, Rezeq Husam Yousef, Almaslamani Muna
Department of Medicine, Hamad General Hospital, Doha, Qatar.
Travel Med Infect Dis. 2009 Mar;7(2):111-7. doi: 10.1016/j.tmaid.2009.01.003. Epub 2009 Feb 7.
A study was conducted to describe the clinical presentation, epidemiology and outcome of imported malaria in patients admitted to Hamad Medical Corporation, Qatar, between 1st January and 31st December 2005. During a one-year study, 81 patients [64 (79%) males and 17 (21%) females] were studied. The median age was 26 years. Most infections were caused by Plasmodium vivax, and Pakistan was the most common area of malaria acquisition. The median times between last arrival in Qatar and the onset of symptoms with Plasmodium falciparum, P. vivax and mixed infections were 14, 28 and 17 days respectively. The median times between onset of symptoms and diagnosis of P. falciparum, P. vivax and mixed infections were 3, 3 and 3.5 days respectively. The predominant symptoms were fever and chill in all patients. High bilirubin and thrombocytopenia were found in 51 (63%) and 47 (58%) of the patients respectively. None had been taking chemoprophylaxis against malaria infection. Six patients had severe falciparum malaria, which was more prevalent among Qatari than non-Qatari patients (p=0.02). No deaths occurred during the study period. The median time of stay in hospital was 3 days; it was longer in patients with P. falciparum infection than in patients with P. vivax (p=0.02). In conclusion, P. vivax is the most common cause of imported malaria, with the majority acquired from the Indian subcontinent. Only a few patients presented with severe malaria. Increased efforts are needed to educate travelers about the need for prophylaxis and other measures.
开展了一项研究,以描述2005年1月1日至12月31日期间入住卡塔尔哈马德医疗公司的输入性疟疾患者的临床表现、流行病学及转归。在为期一年的研究中,共研究了81例患者[64例(79%)男性和17例(21%)女性]。中位年龄为26岁。大多数感染由间日疟原虫引起,巴基斯坦是最常见的疟疾感染地区。恶性疟原虫、间日疟原虫及混合感染患者从最后抵达卡塔尔至出现症状的中位时间分别为14天、28天和17天。恶性疟原虫、间日疟原虫及混合感染患者从出现症状至诊断的中位时间分别为3天、3天和3.5天。所有患者的主要症状为发热和寒战。分别有51例(63%)和47例(58%)患者出现高胆红素血症和血小板减少。无人采取疟疾感染化学预防措施。6例患者患有严重恶性疟疾,在卡塔尔患者中比非卡塔尔患者更常见(p=0.02)。研究期间无死亡病例。住院中位时间为3天;恶性疟原虫感染患者的住院时间比间日疟原虫感染患者长(p=0.02)。总之,间日疟原虫是输入性疟疾最常见的病因,大多数病例来自印度次大陆。只有少数患者出现严重疟疾。需要加大力度对旅行者进行预防及其他措施必要性的教育。