Lipov Eugene G, Joshi Jaydeep R, Sanders Sarah, Slavin Konstantin V
Advanced Pain Centers S.C., 2260 W. Higgins Rd., Ste. 101, Hoffman Estates, IL 60169, USA.
Med Hypotheses. 2009 Jun;72(6):657-61. doi: 10.1016/j.mehy.2009.01.009. Epub 2009 Feb 23.
The mechanism of action of the stellate ganglion block (SGB) is still uncertain; however it has been used successfully in treatment of chronic regional pain syndrome (CRPS) for many years. Our new insights in to the mechanism of action of the stellate ganglion block were first reported in 2007 in our publication detailing the control of hot flashes with the use of stellate ganglion blockade. We have demonstrated very significant results in the treatment of hot flashes and our most recent application of this block has been for the treatment of posttraumatic stress disorder (PTSD). Stellate ganglion has been demonstrated to have second and third order neurons connections with the central nervous system nuclei that modulate body temperature, neuropathic pain, the manifestations of PTSD, and many other areas. We believe that the commonality between the CRPS, HF and PTSD is the trigger of increased nerve growth factor (NGF) leading to the increase in brain norepinephrine (NR), which in turn is affected by the SGB leading to a prolonged reduction of NGF and eventually a decrease in NR. This, in turn, leads to a reduction or elimination of many of the symptoms of CRPS, Hot flashes, and PTSD.
星状神经节阻滞（SGB）的作用机制尚不确定；然而，多年来它已成功用于治疗慢性区域疼痛综合征（CRPS）。我们对星状神经节阻滞作用机制的新见解于2007年首次发表在我们的出版物中，该出版物详细介绍了使用星状神经节阻滞控制潮热。我们在潮热治疗方面取得了非常显著的成果，并且我们最近将这种阻滞应用于创伤后应激障碍（PTSD）的治疗。已证明星状神经节与调节体温、神经性疼痛、PTSD表现及许多其他区域的中枢神经系统核有二级和三级神经元连接。我们认为，CRPS、潮热和PTSD之间的共性是神经生长因子（NGF）增加的触发因素，导致脑去甲肾上腺素（NR）增加，而NR又受SGB影响，导致NGF长期减少，最终NR降低。这反过来又导致CRPS、潮热和PTSD的许多症状减轻或消除。
