法罗培南及其他β-内酰胺类药物与具有不同β-内酰胺敏感性的肺炎链球菌青霉素结合蛋白的结合情况。
Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities.
作者信息
Kosowska-Shick Klaudia, McGhee Pamela, Appelbaum Peter C
机构信息
Department of Pathology, Hershey Medical Center, Hershey, Pennsylvania, USA.
出版信息
Antimicrob Agents Chemother. 2009 May;53(5):2176-80. doi: 10.1128/AAC.01566-08. Epub 2009 Feb 23.
Abstract
Faropenem demonstrated low MICs (< or = 1 microg/ml) for all penicillin-susceptible and nonsusceptible pneumococci and exhibited very strong abilities to bind to Streptococcus pneumoniae penicillin-binding proteins (PBPs), except for PBP2X. The lower faropenem affinity for PBP2X did not affect MICs for any strains tested, and only imipenem had lower MICs, with much lower binding affinities for all PBPs tested, than faropenem.
摘要
法罗培南对所有青霉素敏感和不敏感的肺炎球菌均显示出低 MIC（≤1μg/ml），并且除 PBP2X 外，对肺炎链球菌青霉素结合蛋白（PBPs）具有很强的结合能力。法罗培南对 PBP2X 的亲和力较低，但这并未影响所测试任何菌株的 MIC，只有亚胺培南对所有测试的 PBPs 的结合亲和力远低于法罗培南，且 MIC 更低。
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