FlexPred：一个用于预测蛋白质构象转换中涉及的残基位置的网络服务器。
FlexPred: a web-server for predicting residue positions involved in conformational switches in proteins.
作者信息
Kuznetsov Igor B, McDuffie Michael
机构信息
GenNY*sis Center for Excellence in Cancer Genomics, Department of Epidemiology and Biostatistics, One Discovery Drive, University at Albany, Rensselaer, NY 12144, USA.
出版信息
Bioinformation. 2008;3(3):134-6. doi: 10.6026/97320630003134. Epub 2008 Nov 5.
UNLABELLED
Conformational switches observed in the protein backbone play a key role in a variety of fundamental biological activities. This paper describes a web-server that implements a pattern recognition algorithm trained on the examples from the Database of Macromolecular Movements to predict residue positions involved in conformational switches. Prediction can be performed at an adjustable false positive rate using a user-supplied protein sequence in FASTA format or a structure in a Protein Data Bank (PDB) file. If a protein sequence is submitted, then the web-server uses sequence-derived information only (such as evolutionary conservation of residue positions). If a PDB file is submitted, then the web-server uses sequence-derived information and residue solvent accessibility calculated from this file.
AVAILABILITY
FlexPred is publicly available at http://flexpred.rit.albany.edu.
未标注
在蛋白质主链中观察到的构象转换在多种基本生物活动中起关键作用。本文描述了一个网络服务器，它实现了一种模式识别算法，该算法基于来自大分子运动数据库的示例进行训练，以预测参与构象转换的残基位置。可以使用用户提供的FASTA格式蛋白质序列或蛋白质数据库（PDB）文件中的结构，以可调整的误报率进行预测。如果提交蛋白质序列，那么网络服务器仅使用序列衍生信息（例如残基位置的进化保守性）。如果提交PDB文件，那么网络服务器使用序列衍生信息以及根据该文件计算的残基溶剂可及性。
可用性
FlexPred可在http://flexpred.rit.albany.edu上公开获取。
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