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Is low histamine a fundamental cause of sleepiness in narcolepsy and idiopathic hypersomnia?

作者信息

Scammell Thomas E, Mochizuki Takatoshi

机构信息

Department of Neurology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, El CLS-705, Boston, MA 02215, USA.

出版信息

Sleep. 2009 Feb;32(2):133-4. doi: 10.1093/sleep/32.2.133.

DOI:10.1093/sleep/32.2.133
PMID:19238797
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2635574/
Abstract
摘要

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本文引用的文献

1
CSF histamine contents in narcolepsy, idiopathic hypersomnia and obstructive sleep apnea syndrome.发作性睡病、特发性睡眠增多症和阻塞性睡眠呼吸暂停综合征患者脑脊液中的组胺含量
Sleep. 2009 Feb;32(2):181-7. doi: 10.1093/sleep/32.2.181.
2
Decreased CSF histamine in narcolepsy with and without low CSF hypocretin-1 in comparison to healthy controls.与健康对照组相比，伴或不伴脑脊液中低食欲素-1的发作性睡病患者脑脊液中组胺减少。
Sleep. 2009 Feb;32(2):175-80. doi: 10.1093/sleep/32.2.175.
3
Brain histamine H1 receptor occupancy of orally administered antihistamines, bepotastine and diphenhydramine, measured by PET with 11C-doxepin.通过使用11C-多塞平的正电子发射断层扫描（PET）测量口服抗组胺药贝波司汀和苯海拉明后大脑组胺H1受体占有率。
Br J Clin Pharmacol. 2008 Jun;65(6):811-21. doi: 10.1111/j.1365-2125.2008.03143.x. Epub 2008 Apr 11.
4
Brain structures and mechanisms involved in the control of cortical activation and wakefulness, with emphasis on the posterior hypothalamus and histaminergic neurons.参与控制皮层激活和觉醒的脑结构与机制，重点关注下丘脑后部和组胺能神经元。
Sleep Med Rev. 2000 Oct;4(5):471-503. doi: 10.1053/smrv.2000.0116.
5
Neuronal activity of histaminergic tuberomammillary neurons during wake-sleep states in the mouse.小鼠清醒-睡眠状态下组胺能结节乳头体神经元的神经活动
J Neurosci. 2006 Oct 4;26(40):10292-8. doi: 10.1523/JNEUROSCI.2341-06.2006.
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Altered sleep-wake characteristics and lack of arousal response to H3 receptor antagonist in histamine H1 receptor knockout mice.组胺H1受体基因敲除小鼠的睡眠-觉醒特征改变及对H3受体拮抗剂缺乏唤醒反应
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Extracellular histamine level in the frontal cortex is positively correlated with the amount of wakefulness in rats.大鼠额叶皮质中的细胞外组胺水平与清醒时长呈正相关。
Neurosci Res. 2004 Aug;49(4):417-20. doi: 10.1016/j.neures.2004.05.001.
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Wake-related activity of tuberomammillary neurons in rats.大鼠结节乳头体神经元与觉醒相关的活动
Brain Res. 2003 Dec 5;992(2):220-6. doi: 10.1016/j.brainres.2003.08.044.
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Anatomical, physiological, and pharmacological characteristics of histidine decarboxylase knock-out mice: evidence for the role of brain histamine in behavioral and sleep-wake control.组氨酸脱羧酶基因敲除小鼠的解剖学、生理学和药理学特征：脑组胺在行为及睡眠-觉醒控制中作用的证据
J Neurosci. 2002 Sep 1;22(17):7695-711. doi: 10.1523/JNEUROSCI.22-17-07695.2002.
10
Extracellular histamine levels in the feline preoptic/anterior hypothalamic area during natural sleep-wakefulness and prolonged wakefulness: an in vivo microdialysis study.自然睡眠-觉醒和长时间觉醒期间猫视前区/下丘脑前部区域的细胞外组胺水平：一项体内微透析研究。
Neuroscience. 2002;113(3):663-70. doi: 10.1016/s0306-4522(02)00158-6.