发作性睡病伴猝倒患者的食欲素缺乏发生于疾病发作期间。
Hypocretin deficiency develops during onset of human narcolepsy with cataplexy.
机构信息
Paediatric Department, Blekinge Hospital, Karlskrona, Sweden.
出版信息
Sleep. 2013 Jan 1;36(1):147-8. doi: 10.5665/sleep.2320.
Abstract
STUDY OBJECTIVES
Although hypothesized through animal studies, a temporal and causal association between hypocretin deficiency and the onset of narcolepsy with cataplexy (NC) has never been proven in humans.
SETTING
Paediatric Department, Blekinge Hospital, Sweden, and Danish Center for Sleep Medicine, Glostrup Hospital, Denmark.
PATIENT AND RESULTS
Two weeks after his second Pandemrix-vaccination, a 10 year old HLA-DQB1*0602-positive boy developed NC. The CSF hypocretin-1 level was 10 pg/ml. However, CSF saved from a pre-narcolepsy episode of Lyme disease revealed a normal hypocretin-1 level (318 pg/ml).
CONCLUSIONS
We confirm that hypocretin deficiency develops in parallel to the onset of human narcolepsy with cataplexy.
摘要
研究目的
尽管动物研究假设了下丘脑分泌素缺乏与猝倒性睡眠发作（NC）发作之间存在时间和因果关系，但从未在人类中得到证实。
设置
瑞典布莱金厄医院儿科系和丹麦哥本哈根格洛斯楚普医院睡眠医学中心。
患者和结果
在第二次接种 Pandemrix 疫苗两周后，一名 10 岁 HLA-DQB1*0602 阳性男孩出现 NC。CSF 下丘脑分泌素-1 水平为 10pg/ml。然而，从莱姆病的一次预猝倒发作中保存的 CSF 显示正常的下丘脑分泌素-1 水平（318pg/ml）。
结论
我们证实，人类猝倒性睡眠发作与下丘脑分泌素缺乏症同时发生。
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