[Inhibition of (-)epigallocatechin gallate on dimethylarsinic acid promoting lung tumorigenesis through the induction of oxidative stress in mice].

OBJECTIVE

To investigate inhibition of ((-)epigallocatechin gallate, EGCG) on lung-tumor promotion and oxidative stress caused by administration of dimethylarsinic acid (DMA(V)) in mice.

METHODS

The experimental animal model, which is induced by lung tumor initiator (4NQO) and promoter (DMA(V)) in mice, was used to examine the effect of EGCG on DMA(V) promoting lung tumorigenesis. The 8-oxo-2'-deoxyguanosine (8-oxodG) analysis of lungs were used of HPLC.

RESULTS

The incidence of lung tumors induced by lung tumor initiator (4NQO) and promoter (DMA (V)) were, as well as 8-oxodG, suppressed by cotreatment with (-)epigallocatechin gallate (EGCG).

CONCLUSION

EGCG can inhibit the tumor promotion, which is associated with its inhibition of oxidative stress induced by DMA.