An Yan, Li Zhen, Wang Sanxiang, Wang Zhenghui
Department of Toxicology, School of Radiation Medicine & Public Health Medical College of Soochow University, Suzhou 215123, China.
Wei Sheng Yan Jiu. 2008 Nov;37(6):748-50.
To investigate inhibition of ((-)epigallocatechin gallate, EGCG) on lung-tumor promotion and oxidative stress caused by administration of dimethylarsinic acid (DMA(V)) in mice.
The experimental animal model, which is induced by lung tumor initiator (4NQO) and promoter (DMA(V)) in mice, was used to examine the effect of EGCG on DMA(V) promoting lung tumorigenesis. The 8-oxo-2'-deoxyguanosine (8-oxodG) analysis of lungs were used of HPLC.
The incidence of lung tumors induced by lung tumor initiator (4NQO) and promoter (DMA (V)) were, as well as 8-oxodG, suppressed by cotreatment with (-)epigallocatechin gallate (EGCG).
EGCG can inhibit the tumor promotion, which is associated with its inhibition of oxidative stress induced by DMA.
