Dowdell S J, Metcalfe P E, Morales J E, Jackson M, Rosenfeld A B
Centre for Medical Radiation Physics, University of Wollongong, Wollongong, Australia.
Australas Phys Eng Sci Med. 2008 Dec;31(4):325-31. doi: 10.1007/BF03178602.
Proton therapy (PT) is becoming a more widely available treatment option on the world stage and there is some interest in investment in this treatment option in Australia. The benefit of PT has been shown for a number of tumour sites, particularly for paediatric patients. The workload from these patients may not completely fill the maximum yearly workload of a machine. This work aims to ascertain if prostate cancer would be a suitable candidate to fill the rest of the workload at an Australian PT facility. Passive and intensity modulated proton therapy (IMPT) plans were generated for a prostate patient. These were compared to 7 field sliding window and step and shoot IMRT plans. All plans used a prescription dose of 78 CGE. IMRT and IMPT plans used inverse planning for optimisation. Homogeneity in the PTV was best for the IMPT plan. IMPT also gave the best rectal sparing. The bladder and femoral heads were exposed to less dose in both proton plans. Proton plans exposed normal tissue outside the PTV to less than 50% of the dose given by the IMRT plans. PT, particularly IMPT, is a suitable treatment option for the prostate cancer patient presented here.
质子治疗（PT）在世界范围内正成为一种应用越来越广泛的治疗选择，并且在澳大利亚有人对投资这一治疗选择感兴趣。PT的益处已在多个肿瘤部位得到证实，尤其是对儿科患者。这些患者带来的工作量可能无法完全填满一台机器的最大年度工作量。这项研究旨在确定前列腺癌是否适合填补澳大利亚一家PT机构剩余的工作量。为一名前列腺癌患者制定了被动调强质子治疗（IMPT）计划。将这些计划与7野滑动窗口调强放疗（IMRT）计划和静态调强放疗计划进行比较。所有计划均采用78 CGE的处方剂量。IMRT和IMPT计划使用逆向计划进行优化。IMPT计划的靶区内均匀性最佳。IMPT对直肠的保护也最好。在两种质子治疗计划中，膀胱和股骨头所受剂量较少。质子治疗计划使靶区外正常组织所受剂量低于IMRT计划剂量的50%。PT，尤其是IMPT，是本文所述前列腺癌患者的合适治疗选择。
