Rao Aditya, Yeleswarapu Sri Jyothsna, Srinivasan Rajgopal, Bulusu Gopalakrishnan
Life Sciences R&D Division, TCS Innovation Labs Hyderabad, Tata Consultancy Services Ltd, 1 Software Units Layout, Madhapur, Hyderabad 500081, India.
Indian J Biochem Biophys. 2008 Dec;45(6):365-73.
Protein trafficking in the malarial parasite Plasmodium falciparum is dictated by a complex life-cycle that involves a variety of intra-cellular and host cell destinations, such as the mitochondrion, apicoplast, rhoptries and micronemes. Of these, the apicoplast and mitochondrion are believed to account for more than 10% of this traffic. Studies have shown that mechanisms for mitochondrion and apicoplast targeting are distinct, despite their close physical proximity. The heme biosynthesis pathway spans both these organelles, making trafficking studies crucial for the spatial demarcation of the constituent interactions. This minireview highlights the challenges in identifying the possible sub-cellular destinations of the heme pathway enzymes using gleanings from literature survey as well as focussed bioinformatic analysis.
恶性疟原虫中的蛋白质运输由一个复杂的生命周期决定，该生命周期涉及多种细胞内和宿主细胞目的地，如线粒体、质体、棒状体和微线体。其中，质体和线粒体被认为占这种运输的10%以上。研究表明，尽管线粒体和质体在物理位置上非常接近，但它们的靶向机制是不同的。血红素生物合成途径跨越这两个细胞器，这使得运输研究对于组成相互作用的空间划分至关重要。这篇小型综述强调了利用文献调查结果以及重点生物信息学分析来确定血红素途径酶可能的亚细胞目的地所面临的挑战。
