Toh Shu Qin, Glanfield Amber, Gobert Geoffrey N, Jones Malcolm K
Queensland Institute of Medical Research, Herston, Queensland, 4006, Australia.
Parasit Vectors. 2010 Nov 18;3:108. doi: 10.1186/1756-3305-3-108.
Hemoparasites, like malaria and schistosomes, are constantly faced with the challenges of storing and detoxifying large quantities of heme, released from their catabolism of host erythrocytes. Heme is an essential prosthetic group that forms the reactive core of numerous hemoproteins with diverse biological functions. However, due to its reactive nature, it is also a potentially toxic molecule. Thus, the acquisition and detoxification of heme is likely to be paramount for the survival and establishment of parasitism. Understanding the underlying mechanism involved in this interaction could possibly provide potential novel targets for drug and vaccine development, and disease treatment. However, there remains a wide gap in our understanding of these mechanisms. This review summarizes the biological importance of heme for hemoparasite, and the adaptations utilized in its sequestration and detoxification.
血寄生虫，如疟原虫和血吸虫，一直面临着储存和解毒大量血红素的挑战，这些血红素是它们分解代谢宿主红细胞时释放出来的。血红素是一种必需的辅基，它构成了具有多种生物学功能的众多血红蛋白的反应核心。然而，由于其反应性，它也是一种潜在的有毒分子。因此，血红素的获取和解毒对于寄生虫的生存和寄生关系的建立可能至关重要。了解这种相互作用的潜在机制可能为药物和疫苗开发以及疾病治疗提供潜在的新靶点。然而，我们对这些机制的理解仍然存在很大差距。本综述总结了血红素对血寄生虫的生物学重要性，以及在其螯合和解毒过程中所采用的适应性机制。
