Nusetti Sonia, Salazar Víctor, Lima Lucimey
Laboratorio de Neuroquímica, Centro de Biofísica y Bioquímica, Instituto Venezolano de Investigaciones Científicas, Caracas, Venezuela.
Adv Exp Med Biol. 2009;643:233-42. doi: 10.1007/978-0-387-75681-3_24.
Taurine and zinc interact during structural and functional development of the rat retina and during the process of regeneration of retinal fragments from goldfish. These observations formed the basis for evaluating the regional correlation between the localization of the taurine transporter, taurine content and labile zinc content in goldfish retina. In the retina, the taurine transporter is expressed in photoreceptors, the outer plexiform layer, the inner nuclear layer and the ganglion cell layer. Taurine was detected in photoreceptors, the outer and inner nuclear layers, the outer plexiform layer and the ganglion cell layer. A large amount of labile zinc was detected in photoreceptors and to a lesser extent in ganglion cells. The taurine transporter, taurine and zinc coexist in photoreceptors and the ganglion cell layer. Their co-localization in photoreceptors may be related to the neuro-protective role of taurine and zinc in this layer. By contrast, their co-existence in ganglion cells may be related to their involvement in cell differentiation, development, and regeneration. This reveals the importance of taurine and zinc in maintaining normal cellular function in these particular layers of the retina.
牛磺酸与锌在大鼠视网膜的结构和功能发育过程中以及金鱼视网膜碎片再生过程中相互作用。这些观察结果为评估金鱼视网膜中牛磺酸转运体的定位、牛磺酸含量和不稳定锌含量之间的区域相关性奠定了基础。在视网膜中，牛磺酸转运体在光感受器、外网状层、内核层和神经节细胞层中表达。在光感受器、内核层和外核层、外网状层以及神经节细胞层中均检测到了牛磺酸。在光感受器中检测到大量不稳定锌，在神经节细胞中检测到的量较少。牛磺酸转运体、牛磺酸和锌共存于光感受器和神经节细胞层。它们在光感受器中的共定位可能与牛磺酸和锌在该层中的神经保护作用有关。相比之下，它们在神经节细胞中的共存可能与它们参与细胞分化、发育和再生有关。这揭示了牛磺酸和锌在维持视网膜这些特定层的正常细胞功能中的重要性。
