Doktorovova Slavomira, Souto Eliana B
Faculty of Health Sciences, Fernando Pessoa University, Rua Carlos da Maia 296, 4200-15o Porto, Portugal.
Expert Opin Drug Deliv. 2009 Feb;6(2):165-76. doi: 10.1517/17425240802712590.
The scientific literature today provides several systems that can deliver active pharmaceutical ingredients (APIs) across the skin. These include reservoir matrices, matrix diffusion-controlled devices, multiple polymer devices and multilayer matrix assemblies. Among these, nanostructured lipid carriers (NLC) have emerged as novel systems composed of physiological lipid materials suitable for topical, dermal and transdermal administration. This review focuses on the design characteristics, production and composition of semi-solid formulations containing NLC as API carriers. One of the useful semi-solid systems are hydrogels, which can be used as vehicles to provide appropriate consistency for NLC formulations to be applied onto the skin. In the present review recent developments in the field are highlighted, including examples of APIs successfully entrapped within NLC now amenable for delivery via the skin. Further innovations in NLC composition and formulation, as well as in semi-solid hydrogel assemblies, are likely to expand the number of APIs available for topical, dermal and transdermal delivery.
如今的科学文献提供了多种可透过皮肤递送活性药物成分（API）的系统。这些系统包括储库型基质、基质扩散控制型装置、多重聚合物装置和多层基质组件。其中，纳米结构脂质载体（NLC）已成为由适合局部、真皮和透皮给药的生理性脂质材料组成的新型系统。本综述聚焦于以NLC作为API载体的半固体制剂的设计特点、生产及组成。水凝胶是一种有用的半固体系统，可作为载体为应用于皮肤的NLC制剂提供适宜的稠度。在本综述中突出了该领域的最新进展，包括成功包封于NLC内、现可经皮肤递送的API实例。NLC组成和制剂以及半固体水凝胶组件方面的进一步创新，可能会增加可用于局部、真皮和透皮递送的API数量。
