Saha Sumit, Shahiwala Aliasgar F
National Institute of Pharmaceutical Education and Research (NIPER)-Ahmedabad, C/o. B.V. Patel Pharmaceutical Education and Research Development Centre, S.G. Highway, Thaltej, Ahmedabad-380054, India.
Expert Opin Drug Deliv. 2009 Feb;6(2):197-208. doi: 10.1517/17425240802708978.
With the advancement of tablet manufacturing process, the demand of excipients with improved functionalities, mainly in terms of flow and compression properties, has increased. Coprocessed excipients are a mixture of two or more existing excipients at subparticle level, offer substantial benefits of the incorporated excipients and minimize their drawbacks. These multipurpose excipients have dramatically reduced the number of incorporating excipients in the tablet. The present review discusses the potential advantages of coprocessing and coprocessed excipients, material characteristics required for coprocessing, methods of coprocessing and various coprocessed excipients for direct compression available in the market.
随着片剂制造工艺的进步，对具有改进功能的辅料的需求增加，主要体现在流动性和压缩特性方面。共处理辅料是两种或更多种现有辅料在亚颗粒水平的混合物，兼具所含辅料的显著优点并将其缺点降至最低。这些多功能辅料极大地减少了片剂中所含辅料的数量。本综述讨论了共处理及共处理辅料的潜在优势、共处理所需的材料特性、共处理方法以及市场上可用于直接压片的各种共处理辅料。
