Department of Pediatric Allergy, Baskent University Faculty of Medicine, 06490, Bahcelievler, Ankara, Turkey.
Pediatr Allergy Immunol. 2009 Dec;20(8):741-7. doi: 10.1111/j.1399-3038.2009.00867.x. Epub 2009 Feb 20.
Food allergy has been increasingly reported in children who had orthotopic liver transplantation (OLT). We aimed to conduct a prospective study to investigate the prevalence of sensitizations and food allergy in pediatric OLT recipients. We also aimed to identify potential risk factors. The study group consisted of 28 children (14 male, 14 female, mean age 4.96 +/- 0.76 yrs) who had OLT. Total eosinophil count (TEC), total IgE, and specific IgEs were studied before and 3, 6, 12 months after OLT. Six patients (21%) developed multiple food allergies. Mean age of six patients at OLT who developed food allergy was younger compared to the non-food allergy group (10.2 months vs. 68.9 months, p < 0.05). Food allergy has been developed within 1 yr in 5, and in 20 months in one patient after OLT. All six patients had cow's milk and egg allergy after OLT. Five children developed wheat, one children developed lentil and another one developed peach allergy in addition to cow's milk and egg allergy. Out of six food-allergic patients after OLT, four children developed Epstein-Barr virus (EBV) infection prior to food allergy. Before OLT, TECs and total IgE levels were not differed among food allergic and non-food allergic patients (p > 0.05). Mean of TECs were significantly higher in food allergic group compared to non-food allergic group at each time point after OLT (p < 0.05). Though statistically insignificant, mean of total IgE levels were also higher in the food allergic group (p > 0.05). These findings suggest that food allergy should be considered after OLT in patients who are younger than 1 yr of age, who developed hypereosinophilia, high total IgE levels or EBV viremia.
食物过敏在接受原位肝移植（OLT）的儿童中越来越多地被报道。我们旨在进行一项前瞻性研究，以调查儿科 OLT 受者的致敏和食物过敏患病率。我们还旨在确定潜在的危险因素。研究组包括 28 名儿童（男 14 名，女 14 名，平均年龄 4.96 +/- 0.76 岁），他们接受了 OLT。在 OLT 之前、之后 3、6 和 12 个月，研究了总嗜酸性粒细胞计数（TEC）、总 IgE 和特异性 IgE。6 名患者（21%）出现多种食物过敏。发生食物过敏的 6 名患者的平均年龄比非食物过敏组年轻（10.2 个月对 68.9 个月，p < 0.05）。OLT 后 5 例患者在 1 年内、1 例患者在 20 个月内发生食物过敏。所有 6 名患者在 OLT 后均出现牛奶和鸡蛋过敏。除牛奶和鸡蛋过敏外，5 名儿童还出现小麦过敏，1 名儿童出现扁豆过敏，另 1 名儿童出现桃过敏。OLT 后发生食物过敏的 6 名患者中，4 名患者在食物过敏前发生 Epstein-Barr 病毒（EBV）感染。OLT 前，食物过敏和非食物过敏患者的 TEC 和总 IgE 水平无差异（p > 0.05）。OLT 后各时间点，食物过敏组的 TEC 均值明显高于非食物过敏组（p < 0.05）。食物过敏组的总 IgE 水平也略高，但无统计学意义（p > 0.05）。这些发现表明，在年龄小于 1 岁、发生嗜酸性粒细胞增多症、高总 IgE 水平或 EBV 病毒血症的 OLT 后患者中，应考虑食物过敏。
