University of Washington School of Medicine, Harborview Medical Center, Box 359775, 325 Ninth Avenue, Seattle, WA 98104, USA.
Curr Infect Dis Rep. 2009 Mar;11(2):127-34. doi: 10.1007/s11908-009-0019-1.
Neurosyphilis literally means syphilitic infection of the central nervous system, but it is often referred to incorrectly as "tertiary syphilis." Neurosyphilis can occur at any time in the course of syphilis, even in the earliest, primary, stage. Early forms of neurosyphilis primarily affect the meninges, cerebrospinal fluid, and cerebral or spinal cord vasculature. Late forms of neurosyphilis primarily affect the brain and spinal cord parenchyma. Uveitis and hearing loss related to syphilis are most common in early syphilis and may be accompanied by early neurosyphilis. The treatment for syphilis-related eye disease and hearing loss is the same as the treatment for neurosyphilis. Neurosyphilis is more commonly seen in patients infected with HIV, and much of the recent literature pertains to this risk group. This article provides a critical review of recent literature on the diagnosis, clinical findings, risk factors, and management of neurosyphilis.
神经梅毒的字面意思是梅毒感染中枢神经系统，但它通常被错误地称为“三期梅毒”。神经梅毒可发生在梅毒病程的任何时间，甚至在最早的一期，即原发性梅毒阶段。神经梅毒的早期形式主要影响脑膜、脑脊液和大脑或脊髓血管。晚期神经梅毒主要影响脑和脊髓实质。与梅毒有关的葡萄膜炎和听力损失在早期梅毒中最为常见，可能伴有早期神经梅毒。梅毒相关眼病和听力损失的治疗与神经梅毒的治疗相同。神经梅毒在感染 HIV 的患者中更为常见，近期的大部分文献都涉及这一风险群体。本文对神经梅毒的诊断、临床发现、危险因素和治疗的最新文献进行了批判性回顾。
