异染色质组装的转录支架
Transcriptional scaffolds for heterochromatin assembly.
作者信息
Cam Hugh P, Chen Ee Sin, Grewal Shiv I S
机构信息
Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
出版信息
Cell. 2009 Feb 20;136(4):610-4. doi: 10.1016/j.cell.2009.02.004.
Abstract
Heterochromatin is dynamically regulated during the cell cycle and in response to developmental signals. Recent findings from diverse systems suggest an extensive role for transcription in the assembly of heterochromatin, highlighting the emerging theme that transcription and noncoding RNAs can provide the initial scaffold for the formation of heterochromatin, which serves as a versatile recruiting platform for diverse factors involved in many cellular processes.
摘要
异染色质在细胞周期中以及对发育信号的响应过程中受到动态调控。来自不同系统的最新研究结果表明，转录在异染色质组装中发挥着广泛作用，突出了一个新出现的主题，即转录和非编码RNA可为异染色质的形成提供初始支架，而异染色质是参与许多细胞过程的多种因子的通用招募平台。
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本文引用的文献
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Kcnq1ot1 antisense noncoding RNA mediates lineage-specific transcriptional silencing through chromatin-level regulation.Kcnq1ot1反义非编码RNA通过染色质水平调控介导谱系特异性转录沉默。
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