Michael Nikolaus, Erfurth Andreas, Pfleiderer Bettina
Department of Psychiatry, University Hospital Münster, Germany.
Psychiatry Res. 2009 Apr 30;172(1):78-81. doi: 10.1016/j.pscychresns.2009.01.002. Epub 2009 Feb 23.
Metabolites within the left dorsolateral prefrontal cortex (DLPFC) of six inpatients with bipolar II rapid cycling (RC) during various mood states (depressed, hypomanic, and euthymic), six depressed inpatients with non-RC bipolar disorder (BIPD), and six healthy controls (HC) were assessed by proton magnetic resonance spectroscopy (MRS). We hypothesized that glutamate/glutamine levels should be altered in RC compared with HC. Patients with RC in contrast to BIPD and HC exhibited elevated levels of N-acetylaspartate (NAA), choline (Cho), creatine (Cr), and glutamate/glutamine (Glx) during all mood states. The Glx levels of BIPD compared with HC did not differ significantly; the other metabolites were increased, though less than in RC patients. Our findings of elevated metabolites in patients with RC, especially Glx as a possible marker of cortical activity, indicate that increased neuronal activity may constitute an important neurobiological feature of RC.
通过质子磁共振波谱（MRS）对6例双相II型快速循环（RC）住院患者在不同情绪状态（抑郁、轻躁狂和心境正常）下、6例非RC双相情感障碍（BIPD）抑郁住院患者以及6例健康对照（HC）左侧背外侧前额叶皮质（DLPFC）内的代谢物进行了评估。我们假设，与HC相比，RC患者的谷氨酸/谷氨酰胺水平会发生改变。与BIPD和HC相比，RC患者在所有情绪状态下均表现出N-乙酰天门冬氨酸（NAA）、胆碱（Cho）、肌酸（Cr）和谷氨酸/谷氨酰胺（Glx）水平升高。BIPD患者的Glx水平与HC相比无显著差异；其他代谢物有所增加，不过增幅小于RC患者。我们发现RC患者的代谢物升高，尤其是作为皮质活动可能标志物的Glx，这表明神经元活动增加可能是RC的一个重要神经生物学特征。
