Włodarski Krzysztof, Włodarski Paweł
Department and Division of Histology and Embryology, Center for Bioastructure Research, Medical University of Warsaw.
Ortop Traumatol Rehabil. 2009 Jan-Feb;11(1):1-6.
Leptin, a hormone secreted by adipose tissue, but also by several other tissues, has a dual effect on bone, acting by two independent mechanisms. As a signal molecule with growth factor characteristics, leptin is able to stimulate osteoblastic cells and to inhibit osteoclast formation and activity, thus promoting osteogenesis. However, as a molecule which stimulates sympathetic neurons in the hypothalamus, leptin indirectly inhibits bone formation. This inhibitory effect of leptin mediated by activation of sympathetic nervous system can be abrogated by application of blood pressure-reducing beta-blockers, which also inhibit receptors of hypothalamic adrenergic neurons.
瘦素是一种由脂肪组织分泌，但也可由其他几种组织分泌的激素，它对骨骼有双重作用，通过两种独立的机制发挥作用。作为一种具有生长因子特性的信号分子，瘦素能够刺激成骨细胞，并抑制破骨细胞的形成和活性，从而促进骨生成。然而，作为一种刺激下丘脑交感神经元的分子，瘦素间接抑制骨形成。由交感神经系统激活介导的瘦素这种抑制作用可通过应用降压β受体阻滞剂来消除，β受体阻滞剂也抑制下丘脑肾上腺素能神经元的受体。
