Liu Yong-chun, Yang Zheng-yin
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, People's Republic of China.
Biometals. 2009 Oct;22(5):733-51. doi: 10.1007/s10534-009-9221-8. Epub 2009 Feb 25.
X-ray crystal and other structural analyses indicate that Yb(III) and all four newly synthesized ligands can form a binuclear Yb(III) complex with a 1:1 metal to ligand stoichiometry by octacoordination at the Yb(III) center. Investigations of DNA binding properties show that all the ligands and Yb(III) complexes can bind to Calf thymus DNA through intercalations with the binding constants at the order of magnitude 10(5)-10(7) M(-1), but Yb(III) complexes present stronger affinities to DNA than ligands. All the ligands and Yb(III) complexes may be used as potential anticancer drugs. Investigations of antioxidation properties show that all the ligands and Yb(III) complexes have strong scavenging effects for hydroxyl radicals and superoxide radicals but Yb(III) complexes show stronger scavenging effects for hydroxyl radicals than ligands.
X射线晶体分析和其他结构分析表明，Yb(III)与所有四种新合成的配体可通过Yb(III)中心的八配位形成金属与配体化学计量比为1:1的双核Yb(III)配合物。DNA结合特性研究表明，所有配体和Yb(III)配合物均可通过插入作用与小牛胸腺DNA结合，结合常数在10(5)-10(7) M(-1)数量级，但Yb(III)配合物对DNA的亲和力比配体更强。所有配体和Yb(III)配合物都可作为潜在的抗癌药物。抗氧化性能研究表明，所有配体和Yb(III)配合物对羟基自由基和超氧阴离子自由基都有很强的清除作用，但Yb(III)配合物对羟基自由基的清除作用比配体更强。
