College of Chemistry and Chemical Engineering, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, P.R. China.
J Biochem. 2010 Mar;147(3):381-91. doi: 10.1093/jb/mvp186. Epub 2009 Nov 11.
The Er(III) complexes are prepared from Er(NO(3))(3).6H(2)O and Schiff-base ligands derived from 8-hydroxyquinoline-2-carboxaldehyde with four aroylhydrazines, including benzoylhydrazine, 2-hydroxybenzoylhydrazine, 4-hydroxybenzoylhydrazine and isonicotinylhydrazine, respectively. X-ray crystal and other structural analyses indicate that Er(III) and every ligand can form a binuclear Er(III) complex with nine-coordination and 1: 1 metal-to-ligand stoichiometry at the Er(III) centre. All the Er(III) complexes can bind to calf thymus DNA through intercalation with the binding constants at the order of magnitude 10(6) M(-1), and they may be used as potential anticancer drugs. All the Er(III) complexes have strong scavenging effects for hydroxyl radicals and superoxide radicals; however, complex containing active phenolic hydroxyl group shows stronger scavenging effects for hydroxyl radicals and complex containing N-heteroaromatic substituent shows stronger scavenging effects for superoxide radicals.
铒（III）配合物由 Er(NO(3))(3).6H(2)O 和席夫碱配体组成，席夫碱配体由 8-羟基喹啉-2-甲醛与四种芳酰肼衍生而来，包括苯甲酰肼、2-羟基苯甲酰肼、4-羟基苯甲酰肼和异烟酰肼。X 射线晶体和其他结构分析表明，Er(III)和每个配体可以在 Er(III)中心形成具有九配位和 1:1 金属-配体化学计量比的双核 Er(III)配合物。所有的 Er(III)配合物都可以通过嵌入与小牛胸腺 DNA 结合，结合常数在 10(6)M(-1)的数量级，它们可能被用作潜在的抗癌药物。所有的 Er(III)配合物都对羟基自由基和超氧自由基具有很强的清除作用；然而，含有活性酚羟基的配合物对羟基自由基具有更强的清除作用，而含有 N-杂芳基取代基的配合物对超氧自由基具有更强的清除作用。
