Goel Apul, Sinha Rahul Janak, Dalela Divakar, Sankhwar Satyanarain, Singh Vishwajeet
Department of Urology, Chhatrapati Shahuji Maharaj Medical University, Uttar Pradesh, India.
Urol J. 2009 Winter;6(1):40-4; discussion 44-6.
The purpose of this study was to determine the frequency of androgen decline in the aging male (ADAM) in a group of Indian men working in the health sector.
A free medical health checkup camp was organized for the male workers aged between 40 and 60 years employed in surgical departments of our hospital. Of 180 listed male workers, 170 attended this camp and 157 eligible men participated in the study. After clinical history and systemic inquiry, the participants were requested to complete the Saint Louis University's ADAM questionnaire, and their serum levels of free and total testosterone were measured.
Symptomatic andropause was found in 106 men (67.5%) on the basis of their responses to the questionnaire, of whom 41 (38.7%) had low serum free testosterone levels and 32 (30.2%) had low serum levels of total testosterone. Fifty-one men were asymptomatic according to the questionnaire and in this group, 11 (21.6%) had low serum free testosterone levels and 6 (11.8%) of these had low total testosterone levels. The frequency of andropause was 33.1% on the basis of low serum free testosterone levels and it was 26.1% when both symptoms and low serum free testosterone levels were taken into account.
In our study, the high frequency of symptoms related to ADAM was unusual. This might be due to the nature of the questionnaire itself. Serum free testosterone measurement may be a better single test for diagnosis of hypogonadism than serum total testosterone measurement.
本研究的目的是确定在卫生部门工作的一组印度男性中衰老男性雄激素缺乏(ADAM)的发生率。
为我院外科部门40至60岁的男性员工组织了一次免费的健康体检活动。在列出的180名男性员工中,170人参加了此次活动,157名符合条件的男性参与了研究。在询问临床病史和进行全身检查后,要求参与者填写圣路易斯大学的ADAM问卷,并测量他们血清中的游离睾酮和总睾酮水平。
根据问卷回答,106名男性(67.5%)存在症状性雄激素缺乏,其中41人(38.7%)血清游离睾酮水平低,32人(30.2%)血清总睾酮水平低。根据问卷,51名男性无症状,在这组中,11人(21.6%)血清游离睾酮水平低,其中6人(11.8%)总睾酮水平低。基于血清游离睾酮水平低,雄激素缺乏的发生率为33.1%;当同时考虑症状和血清游离睾酮水平低时,发生率为26.1%。
在我们研究中,与ADAM相关症状的高发生率并不常见。这可能是由于问卷本身的性质。血清游离睾酮测量可能比血清总睾酮测量更适合作为诊断性腺功能减退的单项检测。