Spetz Anna-Clara E, Palmefors Lennart, Skobe R Staffan P, Strömstedt Martin T, Fredriksson Mats G, Theodorsson Elvar, Hammar Mats L
Department of Molecular and Clinical Medicine, Division of Obstetrics and Gynecology, Faculty of Health Sciences, University Hospital, S-581 85, Linköping, Sweden.
Menopause. 2007 Nov-Dec;14(6):999-1005. doi: 10.1097/gme.0b013e318057786b.
To investigate the prevalence of different symptoms of partial androgen deficiency in aging men (PADAM) and to correlate them with blood concentrations of testosterone and bioavailable testosterone.
A total of 370 men, aged 55 to 75 years, were invited to one of three primary healthcare centers in Sweden. They were asked to complete a questionnaire regarding demographic data, medical history, mood status, medication, castration therapy and smoking, exercise and alcohol habits, as well as different symptoms of PADAM. The 10 questions from a previously used questionnaire (the ADAM questionnaire) were included. The men were offered blood tests for analyses of testosterone, follicle stimulating hormone, luteinizing hormone, steroid hormone-binding globulin, and albumin. From these test results, we calculated the bioavailable testosterone.
Of the questionnaires sent out, 81.6% were returned and eligible for evaluation. Blood samples were obtained from 85.8% of men answering the questionnaire. Many of the symptoms, including five from the ADAM questionnaire, were more common in older age groups (P < 0.05). Three symptoms, deterioration in work performance, decreased strength and/or endurance, and bothersome hot flushes, were associated with low bioavailable testosterone and/or testosterone (P < 0.05). Testosterone and bioavailable testosterone did not differ between age groups, but bioavailable testosterone was higher in men with three or fewer symptoms on the ADAM questionnaire.
Symptoms associated with PADAM often occur in an elderly population, but we could only find an association between three symptoms and blood testosterone concentrations, one being bothersome hot flushes. It is likely that these symptoms have a more complex background than only PADAM.
调查老年男性部分雄激素缺乏（PADAM）不同症状的患病率，并将其与睾酮及生物可利用睾酮的血药浓度相关联。
共有370名年龄在55至75岁之间的男性被邀请至瑞典的三个初级医疗保健中心之一。他们被要求填写一份关于人口统计学数据、病史、情绪状态、用药情况、阉割疗法以及吸烟、运动和饮酒习惯的问卷，以及PADAM的不同症状。其中包含了之前使用过的问卷（ADAM问卷）中的10个问题。这些男性接受了血液检测，以分析睾酮、促卵泡激素、促黄体生成素、类固醇激素结合球蛋白和白蛋白。根据这些检测结果，我们计算出生物可利用睾酮。
在发出的问卷中，81.6%被收回并符合评估条件。在回答问卷的男性中，85.8%提供了血样。许多症状，包括ADAM问卷中的五个症状，在老年组中更为常见（P < 0.05）。工作表现恶化、力量和/或耐力下降以及烦人的潮热这三个症状与低生物可利用睾酮和/或睾酮相关（P < 0.05）。睾酮和生物可利用睾酮在不同年龄组之间没有差异，但在ADAM问卷中症状为三个或更少的男性中，生物可利用睾酮更高。
与PADAM相关的症状在老年人群中经常出现，但我们仅发现三个症状与血睾酮浓度之间存在关联，其中之一是烦人的潮热。这些症状的背景可能比单纯的PADAM更为复杂。
