Bogunovic Ljiljana, Doyle Shevaun M, Vogiatzi Maria G
Weill Cornell Medical College, New York, New York, USA.
Curr Opin Pediatr. 2009 Feb;21(1):77-82. doi: 10.1097/MOP.0b013e32831ec338.
The purpose of this review is to provide a comprehensive synopsis of pediatric bone density. Osteoporosis of the adult is a well established clinical problem, and algorithms to diagnose and treat this disease are recognized throughout the medical community. Osteoporosis or 'low bone mass' in pediatrics, on the other hand, is a rather new and evolving area, with certain unique diagnostic and clinical challenges.
Recent findings in the literature include benefits and limitations of pediatric bone densitometry techniques, proper interpretation of the results of these various techniques, efforts to establish standards and guidelines for diagnosing low bone mass in children and adolescents, optimization of bone growth and mineral accrual for life, pediatric bone mineral density and fracture risk prediction, as well as a clearer awareness of bone fragility in children.
Throughout the last decade, great strides have been made in our understanding of pediatric metabolic bone disease. These will be the focus of this review.
本综述旨在全面概述儿童骨密度。成人骨质疏松是一个已被充分认识的临床问题,诊断和治疗该疾病的算法在整个医学界都得到认可。另一方面,儿科的骨质疏松或“低骨量”是一个相对较新且不断发展的领域,存在一些独特的诊断和临床挑战。
文献中的最新发现包括儿童骨密度测量技术的益处和局限性、对这些不同技术结果的正确解读、为建立儿童和青少年低骨量诊断标准和指南所做的努力、为一生优化骨骼生长和矿物质积累、儿童骨矿物质密度和骨折风险预测,以及对儿童骨脆性的更清晰认识。
在过去十年中,我们对儿童代谢性骨病的理解取得了巨大进展。这些将是本综述的重点。