Department of Surgery, Royal Melbourne Hospital, Parkville, Victoria, Australia.
Murdoch Children's Research Institute, Parkville, Victoria, Australia.
BMJ Open. 2019 Jul 4;9(Suppl 3):63-74. doi: 10.1136/bmjopen-2018-022400.
To describe the epidemiology and concordance of bone health in a population-based sample of Australian parent-child dyads at child age 11-12 years.
Population-based cross-sectional study (the Child Health CheckPoint) nested between waves 6 and 7 of the Longitudinal Study of Australian Children (LSAC).
Assessment centres in seven cities around Australia, February 2015-March 2016.
of all participating CheckPoint families (n=1874), bone data were available for 1222 dyads (1271 children, 50% girls; 1250 parents, 86% mothers).
Peripheral quantitative CT (pQCT) of the non-dominant leg scanned at the 4% (distal) and 66% (mid-calf) tibial sites. Stratec XCT 2000 software generated estimates of bone density, geometry and polar stress-strain index.Parent-child concordance were assessed using Pearson's correlation coefficients and multivariable linear regression models. Percentiles were determined using survey weights. Survey weights and methods accounted for LSAC's complex sampling, stratification and clustering within postcodes.
Concordances were greater for the geometric pQCT parameters (periosteal circumference 0.38, 95% CI 0.33 to 0.43; endosteal circumference 0.42, 95% CI 0.37 to 0.47; total cross-sectional area 0.37, 95% CI 0.32 to 0.42) than density (cortical density 0.25, 95% CI 0.19 to 0.30). Mother-child and father-child values were similar. Relationships attenuated only slightly on adjustment for age, sex and body mass index. Percentiles and concordance are presented for the whole sample and by sex.
There is strong parent-child concordance in bone geometry and, to a lesser extent, density even before the period of peak adolescent bone deposition. This geometrical concordance suggests that future intergenerational bone studies could consider using pQCT rather than the more commonly used dual X-ray absorptiometry (DXA).
描述澳大利亚基于人群的亲子对子在儿童 11-12 岁时的骨健康流行病学和一致性。
在澳大利亚儿童纵向研究（LSAC）的第 6 波和第 7 波之间嵌套的基于人群的横断面研究（儿童健康检查点）。
澳大利亚七个城市的评估中心，2015 年 2 月至 2016 年 3 月。
所有参与检查点的家庭（n=1874）中，有 1222 对亲子关系（1271 名儿童，50%为女孩；1250 名父母，86%为母亲）有骨数据。
使用外周定量 CT（pQCT）扫描非优势腿的 4%（远端）和 66%（小腿中段）胫骨部位。Stratec XCT 2000 软件生成骨密度、几何形状和极应力应变指数的估计值。使用 Pearson 相关系数和多变量线性回归模型评估亲子一致性。使用调查权重确定百分位数。调查权重和方法考虑了 LSAC 的复杂抽样、分层和邮政编码内的聚类。
几何 pQCT 参数的一致性更高（骨外膜周长 0.38，95%置信区间 0.33 至 0.43；骨内膜周长 0.42，95%置信区间 0.37 至 0.47；总横截面积 0.37，95%置信区间 0.32 至 0.42）而不是密度（皮质密度 0.25，95%置信区间 0.19 至 0.30）。母亲与孩子和父亲与孩子的值相似。在调整年龄、性别和体重指数后，相关性仅略有减弱。百分位数和一致性按性别和性别呈现。
即使在青少年骨沉积高峰期之前，骨骼几何形状也存在很强的亲子一致性，而且在密度方面的一致性较小。这种几何一致性表明，未来的代际骨骼研究可以考虑使用 pQCT 而不是更常用的双能 X 线吸收法（DXA）。
