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Protein quality control as a strategy for cellular regulation: lessons from ubiquitin-mediated regulation of the sterol pathway.蛋白质质量控制作为细胞调控的一种策略：泛素介导的固醇途径调控的启示
Chem Rev. 2009 Apr;109(4):1561-74. doi: 10.1021/cr800544v.
2
In vivo action of the HRD ubiquitin ligase complex: mechanisms of endoplasmic reticulum quality control and sterol regulation.HRD泛素连接酶复合体的体内作用：内质网质量控制和固醇调节机制
Mol Cell Biol. 2001 Jul;21(13):4276-91. doi: 10.1128/MCB.21.13.4276-4291.2001.
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Targeting NEDD8-activated cullin-RING ligases for the treatment of cancer.靶向NEDD8激活的泛素连接酶用于癌症治疗。
Clin Cancer Res. 2009 Jun 15;15(12):3912-6. doi: 10.1158/1078-0432.CCR-09-0343. Epub 2009 Jun 9.
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Ubiquitination of 3-hydroxy-3-methylglutaryl-CoA reductase in permeabilized cells mediated by cytosolic E1 and a putative membrane-bound ubiquitin ligase.由胞质E1和一种假定的膜结合泛素连接酶介导的通透细胞中3-羟基-3-甲基戊二酰辅酶A还原酶的泛素化。
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Endoplasmic Reticulum-associated Degradation of Pca1p, a Polytopic Protein, via Interaction with the Proteasome at the Membrane.通过与膜上蛋白酶体相互作用实现的多跨膜蛋白Pca1p的内质网相关降解
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Differential regulation of HMG-CoA reductase and Insig-1 by enzymes of the ubiquitin-proteasome system.泛素-蛋白酶体系统的酶对 HMG-CoA 还原酶和 Insig-1 的差异调节。
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ER-associated degradation in protein quality control and cellular regulation.内质网相关降解在蛋白质质量控制和细胞调节中的作用
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Ubiquitin-mediated regulation of 3-hydroxy-3-methylglutaryl-CoA reductase.泛素介导的3-羟基-3-甲基戊二酰辅酶A还原酶的调控
Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):12944-8. doi: 10.1073/pnas.94.24.12944.
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Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum.人类HRD1是一种E3泛素连接酶，参与内质网蛋白质的降解。
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Ubiquitin-mediated regulation of sterol homeostasis.泛素介导的固醇稳态调节。
Curr Opin Cell Biol. 2020 Aug;65:103-111. doi: 10.1016/j.ceb.2020.04.010. Epub 2020 Jun 21.

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Absence of farnesol salvage in and probably in other fungi.法呢醇缺失， 和可能其他真菌中也是如此。
Appl Environ Microbiol. 2024 Jul 24;90(7):e0087424. doi: 10.1128/aem.00874-24. Epub 2024 Jun 28.
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Membralin is required for maize development and defines a branch of the endoplasmic reticulum-associated degradation pathway in plants.膜联蛋白在玉米发育过程中是必需的，它定义了植物中内质网相关降解途径的一个分支。
Proc Natl Acad Sci U S A. 2024 Jun 18;121(25):e2406090121. doi: 10.1073/pnas.2406090121. Epub 2024 Jun 12.
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Yeast Secretes High Amounts of Human Calreticulin without Cellular Stress.酵母在无细胞应激的情况下分泌大量人钙网蛋白。
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Derlin rhomboid pseudoproteases employ substrate engagement and lipid distortion to enable the retrotranslocation of ERAD membrane substrates.Derlin 菱形假蛋白酶利用底物结合和脂质变形来实现 ERAD 膜底物的逆向转运。
Cell Rep. 2021 Oct 19;37(3):109840. doi: 10.1016/j.celrep.2021.109840.
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Inner-nuclear-membrane-associated degradation employs Dfm1-independent retrotranslocation and alleviates misfolded transmembrane-protein toxicity.核内膜相关降解通过 Dfm1 非依赖性的逆向转运来减轻错误折叠的跨膜蛋白毒性。
Mol Biol Cell. 2021 Apr 1;32(7):521-537. doi: 10.1091/mbc.E20-11-0720. Epub 2021 Feb 10.
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HRD Complex Self-Remodeling Enables a Novel Route of Membrane Protein Retrotranslocation.HRD复合物的自我重塑促成了膜蛋白逆向转运的新途径。
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Assays for protein retrotranslocation in ERAD.内质网相关蛋白降解（ERAD）中蛋白质逆向转运的检测方法。
Methods Enzymol. 2019;619:1-26. doi: 10.1016/bs.mie.2019.01.002. Epub 2019 Feb 15.
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"Mallostery"-ligand-dependent protein misfolding enables physiological regulation by ERAD.Mallostery-配体依赖性蛋白质错误折叠使 ERAD 通过生理调节成为可能。
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The degradation pathway of a model misfolded protein is determined by aggregation propensity.一种模型错误折叠蛋白的降解途径由聚集倾向决定。
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The Dfm1 Derlin Is Required for ERAD Retrotranslocation of Integral Membrane Proteins.Dfm1 德尔林对于跨膜整合蛋白的 ERAD 逆行转位是必需的。
Mol Cell. 2018 Jan 18;69(2):306-320.e4. doi: 10.1016/j.molcel.2017.12.012.

本文引用的文献

1
Protein secretion and membrane insertion systems in bacteria and eukaryotic organelles.细菌和真核细胞器中的蛋白质分泌与膜插入系统。
Adv Appl Microbiol. 2008;65:141-97. doi: 10.1016/S0065-2164(08)00606-0.
2
HPV E6, E6AP and cervical cancer.人乳头瘤病毒E6、E6相关蛋白与宫颈癌
BMC Biochem. 2008 Oct 21;9 Suppl 1(Suppl 1):S4. doi: 10.1186/1471-2091-9-S1-S4.
3
Mass spectrometric analysis of type 1 inositol 1,4,5-trisphosphate receptor ubiquitination.1型肌醇1,4,5-三磷酸受体泛素化的质谱分析
J Biol Chem. 2008 Dec 19;283(51):35319-28. doi: 10.1074/jbc.M807288200. Epub 2008 Oct 27.
4
Cue1p is an activator of Ubc7p E2 activity in vitro and in vivo.Cue1p在体外和体内都是Ubc7p E2活性的激活剂。
J Biol Chem. 2008 May 9;283(19):12797-810. doi: 10.1074/jbc.M801122200. Epub 2008 Mar 5.
5
Common and specific mechanisms of AAA+ proteins involved in protein quality control.参与蛋白质质量控制的AAA+蛋白的共同和特定机制。
Biochem Soc Trans. 2008 Feb;36(Pt 1):120-5. doi: 10.1042/BST0360120.
6
Characterization of an ERAD pathway for nonglycosylated BiP substrates, which require Herp.非糖基化结合免疫球蛋白重链结合蛋白（BiP）底物的内质网相关蛋白降解（ERAD）途径的特征分析，该途径需要Herp。
Mol Cell. 2007 Nov 30;28(4):544-54. doi: 10.1016/j.molcel.2007.09.012.
7
A lipid-based model for the creation of an escape hatch from the endoplasmic reticulum.一种基于脂质的用于在内质网中创建逃逸通道的模型。
Nature. 2007 Jul 26;448(7152):435-8. doi: 10.1038/nature06004.
8
Characterization of the physiological turnover of native and inactivated cytochromes P450 3A in cultured rat hepatocytes: a role for the cytosolic AAA ATPase p97?培养大鼠肝细胞中天然和失活细胞色素P450 3A的生理周转特征：胞质AAA型ATP酶p97的作用？
Biochemistry. 2007 Jul 3;46(26):7793-803. doi: 10.1021/bi700340n. Epub 2007 Jun 6.
9
Real-time fluorescence detection of ERAD substrate retrotranslocation in a mammalian in vitro system.在哺乳动物体外系统中对ERAD底物逆向转运进行实时荧光检测。
Cell. 2007 Jun 1;129(5):943-55. doi: 10.1016/j.cell.2007.03.046.
10
SPFH2 mediates the endoplasmic reticulum-associated degradation of inositol 1,4,5-trisphosphate receptors and other substrates in mammalian cells.SPFH2介导哺乳动物细胞中肌醇1,4,5-三磷酸受体及其他底物的内质网相关降解。
J Biol Chem. 2007 Jul 13;282(28):20104-15. doi: 10.1074/jbc.M701862200. Epub 2007 May 14.

Protein quality control as a strategy for cellular regulation: lessons from ubiquitin-mediated regulation of the sterol pathway.

作者信息

Hampton Randolph Y, Garza Renee M

机构信息

Division of Biological Sciences, University of California at San Diego, La Jolla, California 92093, USA.

出版信息

Chem Rev. 2009 Apr;109(4):1561-74. doi: 10.1021/cr800544v.

DOI:10.1021/cr800544v
PMID:19243134
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8530524/
Abstract
摘要