List Karin
Department of Pharmacology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Future Oncol. 2009 Feb;5(1):97-104. doi: 10.2217/14796694.5.1.97.
Pericellular proteases can degrade extracellular matrix proteins and reshape their microenvironment, as well as cleave and activate signaling molecules such as growth factors and their receptors. In this capacity, pericellular proteolysis is essential for multiple biological processes, including development, tissue homeostasis and tissue repair. On the flip side, dysregulated pericellular proteolysis is a hallmark in many pathological conditions including cancer, and is believed to be critically involved in tumor growth, invasion and dissemination of cancer cells to other organs. Matriptase is a member of the family of Type II transmembrane serine proteases, and has been implicated in a variety of epithelial cancers. This review summarizes current knowledge about matriptase and its role in cancer based on expression studies, biochemical characterization, cell-culture based studies and in vivo experiments.
细胞周围蛋白酶能够降解细胞外基质蛋白并重塑其微环境，还能切割并激活诸如生长因子及其受体等信号分子。细胞周围蛋白酶的这种功能对于包括发育、组织稳态和组织修复在内的多种生物学过程至关重要。另一方面，细胞周围蛋白水解失调是包括癌症在内的许多病理状况的一个标志，并且被认为在肿瘤生长、侵袭以及癌细胞向其他器官的扩散中起关键作用。膜型丝氨酸蛋白酶是II型跨膜丝氨酸蛋白酶家族的成员，与多种上皮癌有关。这篇综述基于表达研究、生化特性分析、细胞培养研究以及体内实验，总结了关于膜型丝氨酸蛋白酶及其在癌症中作用的现有知识。
