Antunes C M, Stolley P D
Cancer. 1977 Apr;39(4 Suppl):1896-8. doi: 10.1002/1097-0142(197704)39:4+<1896::aid-cncr2820390824>3.0.co;2-e.
Since 1973, there has been an increase in the reported number of cases of liver tumors (both benign and malignant), associated with the intake of male hormones as anabolic steroids and oral contraceptives. Because these tumors are very rare in the younger age groups, and because there are approximately 50 million women taking oral contraceptives at the present time, there is a definite need for a large-scale epidemiological investigation to clarify this possible association.
自1973年以来,报告的肝脏肿瘤(包括良性和恶性)病例数量有所增加,这与将雄性激素用作合成代谢类固醇和口服避孕药的情况有关。由于这些肿瘤在较年轻年龄组中非常罕见,并且由于目前约有5000万女性服用口服避孕药,因此确实需要进行大规模的流行病学调查以阐明这种可能的关联。