Pyrkov Timothy V, Chugunov Anton O, Krylov Nikolay A, Nolde Dmitry E, Efremov Roman G
M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Ul. Miklukho-Maklaya, 16/10, 117997 GSP, Moscow V-437, Russia.
Bioinformatics. 2009 May 1;25(9):1201-2. doi: 10.1093/bioinformatics/btp111. Epub 2009 Feb 25.
The PLATINUM (Protein-Ligand ATtractions Investigation NUMerically) web service is designed for analysis and visualization of hydrophobic/hydrophilic properties of biomolecules supplied as 3D-structures. Furthermore, PLATINUM provides a number of tools for quantitative characterization of the hydrophobic/hydrophilic match in biomolecular complexes e.g. in docking poses. These complement standard scoring functions. The calculations are based on the concept of empirical Molecular Hydrophobicity Potential (MHP).
The PLATINUM web tool as well as detailed documentation and tutorial are available free of charge for academic users at http://model.nmr.ru/platinum/. PLATINUM requires Java 5 or higher and Adobe Flash Player 9.
Supplementary data are available at Bioinformatics online.
PLATINUM（蛋白质-配体相互作用数值研究）网络服务旨在对以三维结构形式提供的生物分子的疏水/亲水特性进行分析和可视化。此外，PLATINUM提供了许多工具，用于定量表征生物分子复合物（如对接姿势）中的疏水/亲水匹配情况。这些工具补充了标准评分函数。计算基于经验分子疏水性势能（MHP）的概念。
PLATINUM网络工具以及详细的文档和教程可供学术用户在http://model.nmr.ru/platinum/免费使用。PLATINUM需要Java 5或更高版本以及Adobe Flash Player 9.
补充数据可在《生物信息学》在线获取。
