Methlie Camilla Borthen, Schjøtt Jan
Tidsskr Nor Laegeforen. 2009 Feb 26;129(5):420-2. doi: 10.4045/tidsskr.09.33871.
Horse- chestnut seed extract is widely used throughout Europe, and has been used to treat a variety of medical conditions. The most common indication is currently chronic venous insufficiency, for which conventional therapy includes use of compression stockings. Horse chestnut seed extract is generally well tolerated; the most common side effects are gastrointestinal disturbances, dizziness and calf-muscle spasms. Clinical trials have shown that horse- chestnut seed extract and placebo are associated with similar side effects Horse- chestnut may interact with anticoagulants and antidiabetics, and caution is advised in patients taking these drugs. A number of clinical trials have shown that horse- chestnut seed extract may be beneficial to patients with mild to moderate chronic venous insufficiency. However, inadequate randomization, short duration and use of different end-points in these trials makes it difficult to conclude regarding effectiveness and safety, especially in long-term use. Horse- chestnut seed extract appears to be a short-term treatment option in patients with mild to moderate chronic venous insufficiency, but more rigorous trials are required to confirm the efficacy of this treatment.
七叶树籽提取物在欧洲被广泛使用，并且已被用于治疗多种病症。目前最常见的适应症是慢性静脉功能不全，其传统疗法包括使用弹力袜。七叶树籽提取物一般耐受性良好；最常见的副作用是胃肠道不适、头晕和小腿肌肉痉挛。临床试验表明，七叶树籽提取物和安慰剂的副作用相似。七叶树可能与抗凝剂和抗糖尿病药物相互作用，建议服用这些药物的患者谨慎使用。多项临床试验表明，七叶树籽提取物可能对轻至中度慢性静脉功能不全患者有益。然而，这些试验中随机化不足、持续时间短以及使用不同的终点指标，使得难以就其有效性和安全性得出结论，尤其是在长期使用方面。七叶树籽提取物似乎是轻至中度慢性静脉功能不全患者的一种短期治疗选择，但需要更严格的试验来证实这种治疗方法的疗效。
