Bisler H, Pfeifer R, Klüken N, Pauschinger P
Dtsch Med Wochenschr. 1986 Aug 29;111(35):1321-9. doi: 10.1055/s-2008-1068628.
The effect of horse-chestnut seed extract (standardized on aescin; Venostasin retard) was assessed in a randomized placebo-controlled crossover double-blind trial of 22 patients with proven chronic venous insufficiency by measuring the capillary filtration coefficient and the intravascular volume of the lower leg by venous-occlusion plethysmography. Three hours after taking two capsules of Venostasin (600 mg; each capsule containing 50 mg aescin) the capillary filtration coefficient had decreased by 22%, whereas after administration of an identical-looking placebo capsule it rose but slightly over three hours. The difference in the effect of Venostasin and placebo is statistically significant (P = 0.006). The intravascular volume was reduced 5% more after Venostasin than the placebo, but this is not statistically significant. It is concluded that Venostasin has an inhibitory effect on oedema formation via a decrease in transcapillary filtration and thus improves oedema-related symptoms in venous diseases of the legs.
在一项针对22名已确诊为慢性静脉功能不全患者的随机、安慰剂对照、交叉双盲试验中，通过静脉阻塞体积描记法测量小腿的毛细血管滤过系数和血管内容积，评估了马栗树籽提取物（以七叶皂苷标准化；缓释脉通）的效果。服用两粒脉通胶囊（600毫克；每粒胶囊含50毫克七叶皂苷）三小时后，毛细血管滤过系数降低了22%，而服用外观相同的安慰剂胶囊三小时后，该系数略有上升。脉通与安慰剂效果上的差异具有统计学意义（P = 0.006）。脉通使血管内容积比安慰剂多减少了5%，但这无统计学意义。结论是，脉通通过减少跨毛细血管滤过来抑制水肿形成，从而改善腿部静脉疾病中与水肿相关的症状。
