Ciucci Michelle Renee, Connor Nadine P
Division of Otolaryngology, Department of Surgery, University of Wisconsin, 600 Highland Avenue K4/709, Madison, WI 53792, USA.
Exp Brain Res. 2009 Apr;194(4):587-96. doi: 10.1007/s00221-009-1736-2. Epub 2009 Feb 27.
Altering dopamine synaptic transmission can affect both cranial and limb sensorimotor function, but often to a different degree of severity. We hypothesized that haloperidol has dose-dependent but differential effects on lingual forces, lingual movement rates, and limb movement initiation. We measured average and maximal lingual force, tongue press rate and cataleptic descent time in nine Fischer 344/Brown Norway rats in varied doses of haloperidol. Decreases in lingual force and temporal parameters and increases in cataleptic descent time were related to haloperidol dose. However, they were related to a different degree as the relationships were strong between average force and tongue press rate, moderate between maximal force and tongue press rate, moderate between average force and cataleptic descent time, and weak between maximal force and cataleptic descent time. Elucidating the relationships between the cranial and limb sensorimotor systems in the context of altered dopamine synaptic transmission may assist in developing therapies for conditions such as Parkinson's disease.
改变多巴胺突触传递会影响头部和肢体的感觉运动功能，但严重程度往往不同。我们假设，氟哌啶醇对舌力、舌运动速率和肢体运动起始具有剂量依赖性但不同的影响。我们测量了九只Fischer 344/布朗挪威大鼠在不同剂量氟哌啶醇作用下的平均和最大舌力、舌压速率和僵住下降时间。舌力和时间参数的降低以及僵住下降时间的增加与氟哌啶醇剂量有关。然而，它们的相关程度不同，因为平均力与舌压速率之间的关系很强，最大力与舌压速率之间的关系中等，平均力与僵住下降时间之间的关系中等，最大力与僵住下降时间之间的关系较弱。在多巴胺突触传递改变的背景下阐明头部和肢体感觉运动系统之间的关系，可能有助于开发针对帕金森病等病症的治疗方法。
