Department of Communication Sciences and Disorders, University of Wisconsin-Madison, 1975 Willow Drive, Madison, WI 53706, USA.
Behav Brain Res. 2013 Sep 1;252:252-9. doi: 10.1016/j.bbr.2013.06.006. Epub 2013 Jun 10.
Voice disorders manifest in the early stages of Parkinson disease (PD), suggesting the vulnerability of the laryngeal sensorimotor system to mild alterations in dopamine signaling. Previous research has demonstrated that manipulations of central dopamine result in acoustic changes in rat ultrasonic vocalization (USV) and selective manipulation of receptor subtypes results in dose dependent changes in call rate and complexity. However, no study has specifically focused on the influence of dopamine receptor subtypes on acoustic features of USV production. This study examined the influence of D1 and D2 receptor subtypes on voluntary laryngeal sensorimotor control (USV) and gross whole-body involvement. Rat USV acoustics and catalepsy descent time were analyzed following the administration of selective D1 and D2 receptor antagonists in isolation and in combination, and a vehicle control. Results support the hypothesis that degradations of the acoustic signal would be most severe following combined receptor antagonism (D1+D2) compared with D1 or D2 receptor antagonism alone, and the vehicle (saline) condition. In addition, results indicate that selective D1 receptor antagonism alters acoustic parameters to a greater extent than D2 receptor antagonism. Thus, dopamine receptor subtypes appear to influence acoustic parameters to different degrees. Catalepsy descent time was longest following combined dopamine receptor antagonism but was also significantly increased with selective D1 or D2 antagonism. Together, these results support the potentially different contributions receptor subtypes play in cranial and limb sensorimotor control.
嗓音障碍在帕金森病（PD）的早期阶段表现出来，这表明喉感觉运动系统对多巴胺信号的轻微改变很敏感。以前的研究表明，中枢多巴胺的操作会导致大鼠超声发声（USV）的声学变化，而受体亚型的选择性操作会导致叫声率和复杂性的剂量依赖性变化。然而，没有研究专门关注多巴胺受体亚型对 USV 产生的声学特征的影响。本研究检查了 D1 和 D2 受体亚型对自愿性喉感觉运动控制（USV）和全身总参与的影响。在单独和组合使用选择性 D1 和 D2 受体拮抗剂以及载体对照后，分析大鼠 USV 声学和僵直下降时间。结果支持以下假设：与 D1 或 D2 受体拮抗单独或与载体（盐水）条件相比，联合受体拮抗（D1+D2）后，声信号的降解会更严重。此外，结果表明，选择性 D1 受体拮抗会比 D2 受体拮抗更大程度地改变声学参数。因此，多巴胺受体亚型似乎以不同的程度影响声学参数。僵直下降时间在联合多巴胺受体拮抗后最长，但选择性 D1 或 D2 拮抗也显著增加。总之，这些结果支持受体亚型在颅和肢体感觉运动控制中可能发挥不同的作用。
