Department of Cardiology and Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Johann Wolfgang Goethe University of Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.
Exp Gerontol. 2009 May;44(5):363-6. doi: 10.1016/j.exger.2009.02.006. Epub 2009 Feb 25.
We have previously shown that mean telomere length (TL) of granulocytes reflects TL of myeloid bone marrow cells extremely well. Here we analysed the distribution of TL from peripheral blood granulocytes and lymphocytes in 61 female and 68 age-matched male healthy volunteers. We show that the age-dependent decline in TL occurs more rapid in peripheral blood lymphocytes (53 bp/year) than in granulocytes (39 bp/year; p<0.001), while women having longer telomeres than men. We also observed the best correlation for age and telomere length to be present in lymphocytes. The coefficient variation (CV) of TL distribution in granulocytes and monocytes was significantly higher in older compared to younger individuals, indicating an increase in telomere length heterogeneity of myeloid cells and their bone marrow residing precursors during ageing. In a multivariate statistical model, CV and lymphocyte TL were able to explain 50% of chronological ageing.
我们之前已经证明，粒细胞的平均端粒长度（TL）能够极好地反映骨髓细胞的 TL。在这里，我们分析了 61 名女性和 68 名年龄匹配的男性健康志愿者外周血粒细胞和淋巴细胞的 TL 分布。我们发现，TL 随年龄的下降在外周血淋巴细胞中比在粒细胞中更为迅速（53bp/年比 39bp/年；p<0.001），而女性的端粒比男性长。我们还观察到，与年龄和端粒长度的相关性在淋巴细胞中最佳。与年轻个体相比，年长个体粒细胞和单核细胞 TL 分布的变异系数（CV）显著更高，这表明在衰老过程中，髓系细胞及其骨髓前体细胞的端粒长度异质性增加。在多变量统计模型中，CV 和淋巴细胞 TL 能够解释 50%的表型年龄。
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