Qian Yaqin, Ding Tingting, Wei Lijuan, Cao Shui, Yang Lili
Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, People's Republic of China; National Clinical Research Center of Cancer, Tianjin, People's Republic of China; Tianjin Key Laboratory of Cancer Immunology and Biotherapy, Tianjin, People's Republic of China.
National Clinical Research Center of Cancer, Tianjin, People's Republic of China.
Onco Targets Ther. 2016 May 4;9:2675-82. doi: 10.2147/OTT.S98488. eCollection 2016.
Telomere shortening occurs in tumor tissues and peripheral blood lymphocytes of many common human malignancies, including lung cancer, but its variation in T-cells has never been investigated. Thus, the aim of this study was to assess telomere length in T-cells and its correlation with the clinical characteristics of patients with lung cancer.
A total of 40 patients with lung cancer but without prior cancer history and 25 healthy individuals were selected. T-cells were isolated and their telomere lengths were measured using quantitative real-time polymerase chain reaction methods.
Telomere length in T-cells was significantly shorter in patients with lung cancer than in controls (P<0.001). Shorter telomere length was significantly associated with increased clinical stage (P=0.008) and distant metastasis (P=0.028). Naïve T-cells from patients with lung cancer had significantly decreased telomere length when compared with those from controls (P=0.012).
The shortened telomere length in T-cells occurred in naïve T-cells and might be related to lung cancer progression.
端粒缩短发生在包括肺癌在内的许多常见人类恶性肿瘤的肿瘤组织和外周血淋巴细胞中，但其在T细胞中的变化从未被研究过。因此，本研究的目的是评估T细胞中端粒长度及其与肺癌患者临床特征的相关性。
共选取40例无既往癌症病史的肺癌患者和25名健康个体。分离T细胞，并使用定量实时聚合酶链反应方法测量其端粒长度。
肺癌患者T细胞中的端粒长度显著短于对照组（P<0.001）。较短的端粒长度与临床分期增加（P=0.008）和远处转移（P=0.028）显著相关。与对照组相比，肺癌患者的初始T细胞端粒长度显著降低（P=0.012）。
T细胞中端粒长度缩短发生在初始T细胞中，可能与肺癌进展有关。
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