胰高血糖素输注对胆汁淤积性肝炎和梗阻性黄疸患者血浆环磷酸腺苷的影响。肝内胆汁淤积的新检测方法。

Effect of glucagon infusion on plasma cyclic AMP in patients with cholestatic hepatitis and obstructive jaundice. New test of hepatic cholestasis.

作者信息

Francavilla A, Pansini F, Sansone F, Albano O, Martellotta G

出版信息

Clin Chim Acta. 1977 Mar 15;75(3):351-7. doi: 10.1016/0009-8981(77)90352-7.

PMID:192491

Abstract

Plasma cyclic AMP concentration during glucagon infusion at various time intervals was determined in 8 normal subjects, 9 patients with extrahepatic obstructive jaundice and 10 patients with cholestatic hepatitis (hepatitis A and B). Plasma cyclic AMP concentrations (pmol/ml) during glucagon infusion in patients with both obstructive jaundice and cholestatic hepatitis were found to be greater than those in control subjects. In addition, a significant difference in plasma cyclic AMP concentrations was found between patients with cholestatic hepatitis and obstructive jaundice at the 10th minute of glucagon infusion. These results indicate that plasma cyclic AMP levels at the 10th minute of glucagon infusion represent a reliable diagnostic index of cholestatic jaundice.

摘要

在8名正常受试者、9名肝外阻塞性黄疸患者和10名胆汁淤积性肝炎（甲型和乙型肝炎）患者中，测定了不同时间间隔胰高血糖素输注期间的血浆环磷酸腺苷浓度。发现阻塞性黄疸和胆汁淤积性肝炎患者在胰高血糖素输注期间的血浆环磷酸腺苷浓度（pmol/ml）高于对照组。此外，在胰高血糖素输注第10分钟时，胆汁淤积性肝炎患者和阻塞性黄疸患者的血浆环磷酸腺苷浓度存在显著差异。这些结果表明，胰高血糖素输注第10分钟时的血浆环磷酸腺苷水平是胆汁淤积性黄疸的可靠诊断指标。