肝病患者血浆环磷酸腺苷对胰高血糖素的异常反应。
Anomalous plasma cyclic AMP responses to glucagon in patients with liver disease.
作者信息
Maekubo H, Matsushima T, Okada F, Honma M, Ui M
出版信息
Dig Dis Sci. 1980 Sep;25(9):700-4. doi: 10.1007/BF01308330.
PMID:6252000
Abstract
The purpose of the present study is to show anomalies of the plasma cAMP response of patients with hepatic disorders to a single injection of a low dose of glucagon (1 microgram/kg body wt). The response was markedly blunted in patients with liver cirrhosis and potentiated in patients with acute or chronic hepatitis. This glucagon test is, therefore, promising for development as a simple diagnostic means without undertaking liver biopsy to distinguish cirrhosis from chronic hepatitis.
摘要
本研究的目的是展示肝脏疾病患者单次注射低剂量胰高血糖素（1微克/千克体重）后血浆环磷酸腺苷（cAMP）反应的异常情况。肝硬化患者的反应明显减弱，而急性或慢性肝炎患者的反应增强。因此，这种胰高血糖素试验有望发展成为一种简单的诊断方法，无需进行肝活检就能区分肝硬化和慢性肝炎。
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