肝病患者血浆中环磷酸腺苷对胰高血糖素的反应。
Plasma cyclic adenosine-3', 5'-monophosphate response to glucagon in patients with liver disease.
作者信息
Davies T F, Prudhoe K, Douglas A P
出版信息
Br Med J. 1976 Apr 17;1(6015):931-3. doi: 10.1136/bmj.1.6015.931.
Abstract
The change in plasma cyclic adenosine-3', 5'-monophosphate (AMP) was measured after intravenous injection of 1 mg of glucagon in 10 normal subjects and 30 patients with various forms of liver disease. Patients with cirrhosis and those with intrahepatic cholestasis responded normally but in patients with extrahepatic obstruction the plasma cyclic AMP response was considerably increased. Six of the eight patients with cirrhosis and a surgically created portacaval shunt had very reduced responses. This test may prove to be diagnostically important, particularly in differentiating surgical from non-surgical jaundice.
摘要
在10名正常受试者和30名患有各种肝病的患者中，静脉注射1毫克胰高血糖素后，测量了血浆环磷酸腺苷（cAMP）的变化。肝硬化患者和肝内胆汁淤积患者反应正常，但肝外梗阻患者的血浆环磷酸腺苷反应显著增加。8名患有肝硬化并接受手术建立门腔分流术的患者中有6名反应非常减弱。该试验可能证明具有重要的诊断价值，特别是在区分外科性黄疸和非外科性黄疸方面。
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