Read Danielle E, Gorman Adrienne M
Cell Death and Survival Group, Department of Biochemistry, School of Natural Sciences, National University of Ireland, Galway, Ireland.
Biochem Biophys Res Commun. 2009 Apr 24;382(1):6-8. doi: 10.1016/j.bbrc.2009.02.114. Epub 2009 Feb 26.
The small heat shock protein 27 (Hsp27) is well documented to promote neuronal survival in neurodegenerative diseases and following nerve injury. It can directly inhibit apoptotic pathways, and as a chaperone it can ameliorate the toxic effects of misfolded proteins. More recently, Hsp27 has been implicated to also play a role in neurite outgrowth. Thus, Hsp27 is situated at the intersection of neuronal survival and differentiation and, as such, it has dual potential as a key therapeutic target for neuroregeneration.
小热休克蛋白27（Hsp27）在神经退行性疾病及神经损伤后促进神经元存活方面有充分的文献记载。它可直接抑制凋亡途径，并且作为一种伴侣蛋白，它能改善错误折叠蛋白的毒性作用。最近，Hsp27也被认为在神经突生长中发挥作用。因此，Hsp27处于神经元存活与分化的交叉点，正因如此，它作为神经再生的关键治疗靶点具有双重潜力。
