Abdel-Hafez Hisham Zayan, Mahran Ayman Mohamed, Hofny Eman R M, Attallah Dalia Abdel Aziz, Sayed Doaa Sameer, Rashed Hebat-Allah G
Department of Dermatology, Assiut University Hospital, Assiut, Egypt.
J Cosmet Dermatol. 2009 Mar;8(1):52-5. doi: 10.1111/j.1473-2165.2009.00424.x.
Alopecia areata (AA) is an immune-mediated form of hair loss that occurs in all ethnic groups, ages, and both sexes. Helicobacter pylori has been associated with certain extra-digestive dermatological conditions, including chronic urticaria, rosacea, Schönlein-Henoch purpura, Sweet syndrome, systemic sclerosis, and atopic dermatitis.
The causal relation between alopecia areata and H. pylori is discussed. We have screened for the presence of H. pylori in patients with AA in order to determine any potential role in its pathophysiology.
We have prospectively studied 31 patients with AA and 24 healthy volunteers of similar gender for the presence of H. pylori surface antigen (HpSag) in stool.
Optical density values for H. pylori infection were positive in 18 of all 31 patients evaluated (58.1%), while in 13 patients, values did not support H. pylori infection (41.9%). While in the control group, 10 of 24 (41.7%) had positive results. Within the group of AA, there was no significant difference between HpSag-positive and HpSag-negative patients.
Based on these results, the relation between H. pylori and AA is not supported. We advise that H. pylori detection should not be included in the laboratory workup of AA.
斑秃（AA）是一种免疫介导的脱发形式，可发生于所有种族、年龄和性别。幽门螺杆菌已与某些消化系统外的皮肤病相关，包括慢性荨麻疹、酒渣鼻、过敏性紫癜、Sweet综合征、系统性硬化症和特应性皮炎。
探讨斑秃与幽门螺杆菌之间的因果关系。我们对斑秃患者进行了幽门螺杆菌筛查，以确定其在病理生理学中的任何潜在作用。
我们前瞻性地研究了31例斑秃患者和24名性别相似的健康志愿者粪便中幽门螺杆菌表面抗原（HpSag）的存在情况。
在所有31例接受评估的患者中，18例（58.1%）幽门螺杆菌感染的光密度值为阳性，而13例患者的值不支持幽门螺杆菌感染（41.9%）。对照组中，24例中有10例（41.7%）结果为阳性。在斑秃组中，HpSag阳性和HpSag阴性患者之间无显著差异。
基于这些结果，不支持幽门螺杆菌与斑秃之间的关系。我们建议在斑秃的实验室检查中不应包括幽门螺杆菌检测。
