Abdel Hafez Hisham Zayan, Mahran Ayman Mohamed, Hofny Eman M, Attallah Dalia Abdel Aziz, Sayed Doaa Sameer, Rashed Heba
Department of Dermatology, Assiut University Hospital, Egypt.
Indian J Dermatol. 2009;54(1):17-9. doi: 10.4103/0019-5154.48979.
Alopecia areata (AA) is an immune-mediated form of hair loss that occurs in all ethnic groups, ages, and both sexes. Helicobacter pylori has been associated with many extra-digestive dermatological conditions. The causal relation between alopecia areata and Helicobacter pylori is discussed in this study.
We have screened for the presence of H. pylori in patients with AA, in order to determine any potential role in its patho-physiology. We have prospectively studied 31 patients with alopecia areata and 24 healthy volunteers of similar gender, for the presence of H. pylori stool antigen (HpSAg).
Optical density values for H. pylori infection was positive in 18 of the 31 patients evaluated (58.1%), while in 13 patients, the values did not support H. pylori infection (41.9%). In the control group, 10 of the 24 (41.7%) had positive results. Within the group of alopecia areata, there was no significant difference between HpSAg positive and negative patients.
The results have shown that a relation between Helicobacter pylori and alopecia areata is not supported. We advise that H. pylori detection need not to be included in the laboratory work up of alopecia areata.
斑秃（AA）是一种免疫介导的脱发形式，发生于所有种族、年龄和性别。幽门螺杆菌与许多非消化性皮肤病有关。本研究探讨斑秃与幽门螺杆菌之间的因果关系。
我们对斑秃患者进行了幽门螺杆菌检测，以确定其在病理生理学中的潜在作用。我们前瞻性地研究了31例斑秃患者和24名性别相似的健康志愿者，检测其粪便幽门螺杆菌抗原（HpSAg）。
在31例接受评估的患者中，18例（58.1%）幽门螺杆菌感染的光密度值为阳性，而13例患者的值不支持幽门螺杆菌感染（41.9%）。在对照组中，24例中有10例（41.7%）结果为阳性。在斑秃组中，HpSAg阳性和阴性患者之间无显著差异。
结果表明，幽门螺杆菌与斑秃之间不存在关联。我们建议，斑秃的实验室检查无需包括幽门螺杆菌检测。
