Inserm U605 Institut Gustave Roussy Université Paris XI, Villejuif, France.
Clin Endocrinol (Oxf). 2009 Dec;71(6):880-3. doi: 10.1111/j.1365-2265.2009.03561.x. Epub 2009 Feb 25.
Radiation is known to be mutagenic. The present study analyses birth outcomes and the health of offspring from men previously exposed to (131) I treatment for thyroid carcinoma.
Data on 493 pregnancies (356 from 173 untreated fathers, 23 from 17 patients who have undergone surgery alone and 114 from 63 fathers who received (131) I) were obtained by interviewing male patients treated for thyroid carcinoma who had not received significant external radiation to the testes. Among these pregnancies, 73 were conceived from fathers who had received more than 370 MBq.
The mean activity for the 114 pregnancies fathered by 63 patients was 3993 MBq leading to an estimated radiation dose of 9.2 cGy to the testes (MIRD committee coefficient). No significant differences between untreated and treated fathers were found for any adverse outcome.
There was no evidence that exposure to radioiodine affects the outcome of subsequent pregnancies and offspring, whatever the event considered. As our study is underpowered, the question of whether testicular irradiation, fractionated or not, is linked to impaired fertility or consequences on offspring remains to be established.
已知辐射具有致突变性。本研究分析了曾接受（131）I 治疗甲状腺癌的男性的后代的生育结果和健康状况。
通过对未接受睾丸外照射的甲状腺癌男性患者进行访谈，获得了 493 例妊娠（356 例来自 173 例未经治疗的父亲，23 例来自仅接受手术治疗的 17 例患者，114 例来自接受（131）I 治疗的 63 例父亲）的数据。在这些妊娠中，有 73 例是接受超过 370 MBq 辐射的父亲所孕育。
63 例患者的 114 例妊娠的平均活度为 3993 MBq，导致睾丸辐射剂量估计为 9.2 cGy（MIRD 委员会系数）。未发现未经治疗的父亲和接受治疗的父亲在任何不良结局方面存在差异。
无论考虑哪种情况，接触放射性碘都不会影响随后的妊娠和后代的结局。由于本研究的效力不足，仍需要确定睾丸照射（不分段或分段）是否与生育能力受损或对后代的影响有关。
