Bennett Lindsey K, Hinshaw Molly
Department of Dermatology, University of Wisconsin, Madison, Wisconsin 53715, USA.
Pediatr Dermatol. 2009 Jan-Feb;26(1):87-9. doi: 10.1111/j.1525-1470.2008.00830.x.
Focal epithelial hyperplasia, or Heck's disease, is an uncommon proliferation of oral mucosa that presents primarily in Native Central and South American populations. It presents as asymptomatic papules or nodules on the oral mucosa, gingiva, tongue, and lips. In the majority of cases, human papilloma virus 13 or 32 is detected. Factors that determine disease susceptibility are unclear, but genetics, and having the human lymphocytic antigen-DR4 (DRB1*0404) allele in particular, are thought to play a major role in disease vulnerability. We report another case of focal epithelial hyperplasia, hypothesize on disease susceptibility, and review the current understanding of this uncommon disorder.
局灶性上皮增生，即赫克氏病，是一种不常见的口腔黏膜增生性疾病，主要见于美洲中部和南部的原住民群体。它表现为口腔黏膜、牙龈、舌头和嘴唇上的无症状丘疹或结节。在大多数病例中，可检测到人乳头瘤病毒13型或32型。决定疾病易感性的因素尚不清楚，但遗传学因素，尤其是携带人类淋巴细胞抗原-DR4（DRB1*0404）等位基因，被认为在疾病易感性中起主要作用。我们报告了另一例局灶性上皮增生病例，对疾病易感性进行了推测，并综述了目前对这种罕见疾病的认识。
