An-eX, Redwood Building, King Edward VII Avenue, Cardiff, CF1 3XF, UK.
Int J Cosmet Sci. 1994 Oct;16(5):199-210. doi: 10.1111/j.1467-2494.1994.tb00097.x.
Summary The use of ATR-FTIR spectroscopy for the assessment of synthetic and biological membrane permeability is described. Measurement of the diffusion coefficient of acetonitrile in a polydimethylsiloxane membrane showed the method to be of reasonable reproducibility. It has been demonstrated that the concurrent measurement of both solvent and solute permeability is feasible and that the deconvolution of the diffusion and partition coefficients of these species is theoretically possible. Where the diffusing species changed the nature of the membrane a correcting normalization routine was performed by assessing the state of the membrane as a function of time. The use of this method for the routine investigation of membrane permeation phenomena has great potential for the future.
摘要 本文描述了使用衰减全反射傅里叶变换红外光谱（ATR-FTIR）来评估合成和生物膜的通透性。测量乙腈在聚二甲基硅氧烷膜中的扩散系数表明，该方法具有合理的重现性。已经证明，同时测量溶剂和溶质的通透性是可行的，并且这些物质的扩散和分配系数的解卷积在理论上也是可能的。当扩散物质改变了膜的性质时，通过评估膜随时间的状态来进行校正归一化处理。该方法在未来对膜渗透现象的常规研究中有很大的应用潜力。
