Tralhão A M, Watkinson A C, Brain K R, Hadgraft J, Armstrong N A
Welsh School of Pharmacy, UWCC, Cardiff, United Kingdom.
Pharm Res. 1995 Apr;12(4):572-5. doi: 10.1023/a:1016262215192.
The use of ATR-FTIR spectroscopy to study the permeability of a glycerogelatin film is described. Measurement of the diffusion coefficient of ethyl alcohol-d in the film showed excellent reproducibility. Comparison of results from this technique with those previously obtained using an air-flow receptor phase diffusion cell show good agreement in terms of lag time assessed diffusion coefficients. ATR-FTIR spectroscopy revealed time-dependent changes in the composition of the glycerogelatin film during the diffusional process. It was also demonstrated that the concurrent assessment of both diffusant penetration and film composition is feasible.
描述了使用衰减全反射傅里叶变换红外光谱（ATR-FTIR）来研究明胶甘油膜的渗透性。对乙醇-d在该膜中的扩散系数进行测量，结果显示出良好的重现性。将该技术所得结果与先前使用气流受体相扩散池获得的结果进行比较，在滞后时间和评估的扩散系数方面显示出良好的一致性。ATR-FTIR光谱揭示了在扩散过程中明胶甘油膜成分随时间的变化。还证明了同时评估扩散剂渗透和膜成分是可行的。
