McKelvie James, Ku Judy Y, McArdle Brian, McGhee Charles
Department of Ophthalmology, University of Auckland, and Auckland City Hospital, Auckland, New Zealand.
J Cataract Refract Surg. 2009 Mar;35(3):547-55. doi: 10.1016/j.jcrs.2008.11.048.
To characterize and compare the higher-order aberrations (HOAs) in 3 intraocular lenses (IOLs) designed to minimize HOAs using a new physical model eye.
Department of Ophthalmology, University of Auckland, New Zealand.
Measurements of higher-order wavefront aberrations were obtained using the Zywave aberrometer and a purpose-built physical model eye. The following IOLs were included: AcrySof IQ IOL SN60WF aspheric, Tecnis ZA9003 aspheric, and Adapt Advanced Optics. Individual Zernike modes were compared using analysis of variance (ANOVA). Fifteen assessments were made of each of 36 individual IOLs (N = 540) at 3 powers (10.0 diopters [D], 20.0 D, 30.0 D), and 18 Zernike modes were compared using multiple ANOVA and canonical discrimination analysis.
The 3 IOL models at the 3 powers showed significantly different profiles of HOA. Statistical differences were recorded for 10 of 18 individual Zernike modes analyzed for an interaction between model and power. The IOLs of the same model appeared to group together in multivariate analysis. Intraocular lenses of a lower power tended to cluster toward the center of the canonical discrimination analysis, while higher-power IOLs were more peripherally located and appeared least similar.
Validation experiments using the model eye platform showed high reproducibility and low error. The 3 IOLs had statistically different aberration profiles. Higher-power IOLs had greater differences when analyzed using multivariate techniques. Profiling the HOAs of IOLs may assist in the selection of the most appropriate IOL to maximize visual outcome for a given patient after cataract surgery.
使用一种新型物理模型眼来表征和比较3种旨在使高阶像差（HOA）最小化的人工晶状体（IOL）中的高阶像差。
新西兰奥克兰大学眼科系。
使用ZyWave像差仪和专门构建的物理模型眼获取高阶波前像差的测量值。纳入以下人工晶状体：AcrySof IQ IOL SN60WF非球面型、Tecnis ZA9003非球面型和Adapt Advanced Optics。使用方差分析（ANOVA）比较各个泽尼克模式。在3种屈光度（10.0屈光度[D]、20.0 D、30.0 D）下对36个单独的人工晶状体中的每一个进行15次评估（N = 540），并使用多元方差分析和典型判别分析比较18个泽尼克模式。
3种屈光度下的3种人工晶状体模型显示出明显不同的高阶像差分布。在分析的18个单独泽尼克模式中的10个中记录到模型与屈光度之间相互作用的统计学差异。在多变量分析中，同一模型的人工晶状体似乎聚集在一起。较低屈光度的人工晶状体倾向于聚集在典型判别分析的中心，而较高屈光度的人工晶状体位于更外围，且看起来最不相似。
使用模型眼平台进行的验证实验显示出高重现性和低误差。这3种人工晶状体具有统计学上不同的像差分布。使用多变量技术分析时，较高屈光度的人工晶状体差异更大。分析人工晶状体的高阶像差可能有助于选择最合适的人工晶状体，以使白内障手术后特定患者的视觉效果最大化。
