Schouten Eveline A, Schiemanck Sven K, Brand Nico, Post Marcel W M
Center of Excellence for Rehabilitation Medicine, Rehabilitation Center De Hoogstraat, Utrecht, the Netherlands.
J Stroke Cerebrovasc Dis. 2009 Mar-Apr;18(2):128-38. doi: 10.1016/j.jstrokecerebrovasdis.2008.09.017.
We investigated the relationship between ischemic lesion characteristics (hemispheric side, cortical and subcortical level, volume) and memory performance, 1 year after stroke. Verbal and visual memory of 86 patients with stroke were assessed with Rey Auditory-Verbal Learning Test and the Doors Test, respectively. Lesion characteristics and presence of white matter lesions were assessed on magnetic resonance imaging early after stroke. Multiple regression analyses were used to investigate prediction of verbal and visual memory performance by lesion side (left v right hemisphere), lesion level (cortical v subcortical), and lesion volume. We controlled for the influence of demographic characteristics, language disability, and visuospatial difficulties on memory. The results demonstrated that poor verbal memory (immediate and delayed recall and recognition) could be predicted by lesion characteristics: patients with left hemispheric, subcortical, and large lesions showed poor memory performance. Poor visual recognition memory could not be predicted by lesion characteristics but only by low educational level. Our results suggest that lesion characteristics play an important role in episodic verbal memory poststroke if demographic and clinical characteristics are taken into account.
我们研究了卒中1年后缺血性病变特征（半球侧、皮质和皮质下水平、体积）与记忆表现之间的关系。分别采用雷氏听觉词语学习测验和门测验对86例卒中患者的言语记忆和视觉记忆进行评估。在卒中后早期通过磁共振成像评估病变特征和白质病变的存在情况。采用多元回归分析研究病变侧（左半球对右半球）、病变水平（皮质对皮质下）和病变体积对言语和视觉记忆表现的预测作用。我们控制了人口统计学特征、语言障碍和视觉空间困难对记忆的影响。结果表明，病变特征可预测言语记忆较差（即刻和延迟回忆及识别）：左半球、皮质下和大病变的患者记忆表现较差。病变特征不能预测视觉识别记忆较差，而只能通过低教育水平来预测。我们的结果表明，如果考虑到人口统计学和临床特征，病变特征在卒中后情景性言语记忆中起重要作用。
